A native microorganism, Penicillium citrinum was isolated from the top soil of a manganese mine. Based on its efficiency for manganese solubilisation, it was utilized for the leaching of a low-grade manganese ore. The effects of various parameters such as pulp density, particle size, sucrose concentration, inoculum size and bioleaching duration on manganese ore were studied. The optimised condi...

We measured the manganese content of whole blood, plasma, platelets, mononucleated cells, polymorphonucleated cells, and erythrocytes. Platelets and blood cells were separated from whole blood by use of discontinuous gradients of colloidal polyvinylpyrrolidone-coated silica (Percoll), and their manganese content was measured by Zeeman graphite furnace atomic absorption spectrophotometry, after ...

Manganese is capable of forming complex ions with many substances found naturally in the body (1). It seems reasonable to assume, therefore, that manganese injected as MnSO4 (hereafter referred to as "ionic manganese") will be complexed in the body to a varying extent shortly after administration. If the Mn is strongly chelated before it is injected, a state of competition between ligands is se...

there is some evidence supporting the reduced activity of integrins following chronic administration of morphine. this reduction might play a role in morphine tolerance development. manganese binds to the extracellular domain of integrins and makes them to be activated. the effect of integrins activation using manganese on tolerance development to the analgesic effect of morphine was investigat...

BACKGROUND Manganese is both an essential element and a known toxicant, and it plays important roles in many mechanisms in relation to type 2 diabetes (T2D). However, epidemiological studies of this relationship are rare. OBJECTIVE We investigated the association between plasma manganese and newly diagnosed T2D as well as whether the association could be modified by manganese superoxide dismu...

UNLABELLED Streptococcus pyogenes (group A Streptococcus [GAS]) is an obligate human pathogen responsible for a spectrum of human disease states. Metallobiology of human pathogens is revealing the fundamental role of metals in both nutritional immunity leading to pathogen starvation and metal poisoning of pathogens by innate immune cells. Spy0980 (MntE) is a paralog of the GAS zinc efflux pump ...

BACKGROUND Manganese-oxides are one of the most important minerals in soil due to their widespread distribution and high reactivity. Despite their invaluable role in cycling many redox sensitive elements, numerous unknowns remain about the reactivity of different manganese-oxide minerals under varying conditions in natural systems. By altering temperature, pH, and concentration of arsenite we w...

Manganese is an essential trace element required for normal development and bodily functions. However, exposure of the brain to excessive amounts of manganese results in neurotoxicity. Although previous studies examining manganese neurotoxicity have focused on neuronal injury, especially direct injury to dopaminergic neurons, the effects of manganese-induced neurotoxicity on glial cells have no...