Androgen insensitivity syndrome (AIS) is the most common single entity that results in male under-masculinization, but large cohort studies of AIS have rarely been performed. Over the last decade, nationwide cooperation between pediatric endocrinologists in the United Kingdom has allowed the creation of a database of cases of intersex and ambiguous genitalia where detailed clinical information ...

Using DNA-cellulose affinity chromatography and either 3H-labeled dihydrotestosterone, testosterone, or estradiol, we qualitatively and quantitatively analyzed the androgenand estrogen-binding activities present in four regions of male and female ferret brain at prenatal, early and late neonatal, and adult ages. The cytosolic androgenand estrogen-binding activities in ferret brain at all ages s...

Tumours of the ovary accompanied by signs of masculinization (or defeminization) such as amenorrhea, hirsutism and enlargement of the clitoris are uncommon and there appears to be a great deal of confusion regarding their histogenesis. As some of these neoplasms histologically resemble testicular tissue, it is believed that they originate from remnants of the primitive sex cords or potentially ...

The 46 XX, testicular sex differentiation disorder, or XX male syndrome, is a rare condition detected by cytogenetics, in which testicular development occurs in the absence of the Y chromosome. It occurs in 1:20,000 to 25,000 male newborns and represents 2% of cases of male infertility. About 90% of individuals present with normal phenotype at birth and are generally diagnosed after puberty for...

PURPOSE: The number of Lower Body Lift surgeries following massive weight loss has increased considerably over the last ten to fifteen years. Although techniques have improved, the problem of masculinization in females, with an unnatural cinched waist and maximum projection at the greater trochanteric point, persists in a high proportion of patients. Numerous techniques for autologous augmentat...

The Caenorhabditis elegans F-box protein SEL-10 and its human homolog have been proposed to regulate LIN-12 Notch signaling by targeting for ubiquitin-mediated proteasomal degradation LIN-12 Notch proteins and SEL-12 PS1 presenilins, the latter of which have been implicated in Alzheimer's disease. We found that sel-10 is the same gene as egl-41, which previously had been defined by gain-of-func...

To understand the sex reversal characteristics in the longtooth grouper (Epinephelus bruneus), this study examined the sex reversal and artificial masculinization of wild caught E. bruneus reared in indoor rearing tank after a 17α-methyltestosterone injection. To domesticate a broodstock, 64 wild caught E. bruneus, between 47.0 to 110.0 cm in total length and from 1.5 to 21.4 kg in body weight,...