BACKGROUND Prolactin is an anterior pituitary hormone that may modulate the adverse effects of obesity. Prolactin has been associated with cardiovascular disease mortality, but less is known about whether prolactin predicts incidence of cardiovascular disease risk factors. METHODS AND RESULTS Our sample (n=3232, mean age 40.4 years, 52.1% women) was drawn from Framingham Heart Study participa...

Protein activity and turnover is tightly and dynamically regulated in living cells. Whereas the three-dimensional protein structure is predominantly determined by the amino acid sequence, posttranslational modification (PTM) of proteins modulates their molecular function and the spatial-temporal distribution in cells and tissues. Most PTMs can be detected by protein and peptide analysis by mass...

The migration process of contamination materials in the porous rock mass was visualized and analyzed by X-ray CT image data. In this study, Kimachi sandstone, which had approximately 26% porosity, was used as a rock sample. Here two cases of diffusion phenomena were analyzed. One is the case that solute diffuses into the porous rock mass from the crack surfaces, and it simulates the contaminati...

The nanofabrication of a nanomachined holed structure localized on the free end of a microcantilever is here presented, as a new tool to design micro-resonators with enhanced mass sensitivity. The proposed method allows both for the reduction of the sensor oscillating mass and the increment of the resonance frequency, without decreasing the active surface of the device. A theoretical analysis b...

In male adolescent rats kidney mass attained maximum terminal value already at week 1 after streptozotocin treatment, and this value did not change over the next two weeks. At week 1 the kidney size of diabetic rats was greater than that of untreated controls, whereas at week 3 renal mass was the same in both groups. In adult rats with final body and kidney mass streptozotocin treatment failed ...