Background and objective Gingival bleeding reduction in smokers has been associated with decreased blood vessel density. The mechanism of suppressive effect of cigarette smoking on blood vessel density is not precisely defined. The aim of this study was to evaluate the impact of smoking on angiogenesis by assessing mast cells density and VEGF expression in chronic periodontitis. Materials& Me...

Primary cutaneous lymphomas (PCLs) are clonal T- or B-cell neoplasms, which originate in the skin. In recent years, mast cells were described as regulators of the tumor microenvironment in different human malignancies. Here, we investigated the role of mast cells in the tumor microenvironment of PCL. We found significantly increased numbers of mast cells in skin biopsies from patients with cuta...

In the short article by Prof. Ratner on mast cell activation syndrome and its overlooked or dismissed possible contribution to bladder pain syndrome/interstitial cystitis (BPS/IC) (1), the author outlines that increased numbers of activated mast cells (mast cell activation syndrome) may play a role in the development of painful BPS/IC. This association has been long recognized by the European S...

background periapical lesions are induced in response to injuries to periapical tissues, which are generally the result of infections within the root canal. mast cells actively participate to the inflammatory infiltration of periapical granulomas and cysts. objectives the aim of this study was to detect and compare the presence of mast cells in inflammatory periapical lesions, including cysts a...

this study investigated the presence of mast cells in inflammatory aural polyps using light microscopy. the number of mast cells was increased in all examined cases and varied from 2.33 to 41.54 per mm2• the cells were located most commonly around small blood vessels. occurrence of mast cells was not different in various types of polyps, but their density was severely increased in active inflam...

OBJECTIVE To determine eosinophil and mast cell populations in gastric and duodenal mucosal biopsies of adults with nonulcer dyspepsia (NUD) as compared to non-dyspeptic adults. STUDY DESIGN A case control study. PLACE AND DURATION OF STUDY Shahid Sadoughi University of Medical Sciences, Yazd, Iran, from January 2010 to June 2011. METHODOLOGY A total of 52 (25 non-ulcer dyspeptic patients...

Diabetic cardiomyopathy is a specific disease process distinct from coronary artery disease and hypertension. The disease features cardiac remodeling stimulated by hyperglycemia of the left ventricle wall and disrupts contractile functions. Cardiac mast cells may be activated by metabolic byproducts resulted from hyperglycermia and then participate in the remodeling process by releasing a multi...

BACKGROUND Squamous cell carcinoma (SCC) is the most common malignancy in oral cavity. Angiogenesis is essential for the development and progression of SCC. Recently, some studies have reported that mast cells may play a role in tumor progression via promoting angiognesis. Since the results of various studies on the role of mast cells in tumor progression is not uniform, the aim of this study w...

Because of its dynamic structure, the omentum plays a key role in the immunity of the peritoneal cavity by orchestrating peritoneal cell recruitment. Because mast cells accumulate in the omentum upon experimental peritoneal dialysis (PD) and may produce angiogenic/profibrotic factors, it was hypothesized that mast cells mediate omental tissue remodeling during PD. Daily treatment with conventio...