Few studies have examined how raising grandchildren influences the marital relationship of grandparent caregivers even though raising grandchildren may strain marital relationships. This study used nationally representative data from MIDUS to contrast perceptions of spousal relations for grandparents who had recently provided care for grandchildren along with their own young children (n=21), wi...

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Two-hundred and eighteen low-income, minority, adolescent mothers were interviewed during the perinatal period and 3 years later about their social networks, including their relationships with their children's fathers. Few adolescents were involved with fathers at both time points. Relationships with fathers were, in general, less supportive and less problematic over time. Moreover, although fa...

BACKGROUND A number of studies have assessed ages of parents of children with autistic spectrum disorders (ASD), and reported both maternal and paternal age effects. Here we assess relationships with grandparental ages. METHODS AND FINDINGS We compared the parental and grandparental ages of children in the population-based Avon Longitudinal Study of Parents and Children (ALSPAC), according to...

We previously mapped a maternal locus responsible for biparental complete hydatidiform moles (BiCHMs) to 19q13.4. The two index patients had a total of 14 molar pregnancies, eight abortions at various developmental stages, and one 16-year-old healthy offspring. We suggested that the defective gene deregulates the expression of imprinted genes. Here, we report the methylation status of four impr...

CONTEXT Hereditary pancreatitis is typically caused by the PRSS1 R122H or N29I mutations resulting in high penetrance (about 80%) autosomal dominant disorder that is usually reported in North America, Northern Europe and Northeast Asia, but not South America, Africa or India. CASE REPORT Here we report a kindred from Venezuela, South America with the PRSS1 R122H variant. Only the proband, an ...

Copyright © 2008 Massachusetts Medical Society. After the sudden death of a 13-year-old girl while she was playing basketball, her family comes to the clinic for medical evaluation (Fig. 1). Her parents’ resting electrocardiograms (ECGs) are normal, but her 9-year-old sister’s ECG shows an abnormally long QT interval. There is a history of recurrent syncope in female relatives of the maternal g...

A 50-year-old man presented with congenital scaling and hyperkeratosis on his palms, the soles of his feet and the extensor areas of his joints. The flexural areas were unaffected. His maternal grandmother, questionably his maternal uncle, his mother, all three brothers, one of his two sisters as well as two nephews and three nieces have or had similar skin changes. A punch biopsy was taken fro...

Birth weight is an indicator of prenatal development associated with health in infancy and childhood, and may be affected by the family environment experienced by the mother during pregnancy. Using data from KwaZulu-Natal, South Africa, we explore the importance of the mother's access to the father and grandparents of the child during pregnancy. Controlling for household socio-economic indicato...

A Chinese family with hemoglobin H in the propositus has been reinvestigated. Although the original propositus is now deceased, a sister has the same hematological manifestations. Her hemoglobin, like that of the deceased sister, contains hemoglobins A, H, and Bart's. In addition, however, two minor components have been detected. These minor components appear to have abnormal alpha-chains and a...