OBJECTIVE To evaluate the Neonatal Screening Program in the State of Tocantins from 1995 to 2011. MATERIALS AND METHODS Data collection was conducted by means of interviews with those responsible for the service, by the analysis of medical records of patients diagnosed with phenylketonuria (PKU) and congenital hypothyroidism (CH) that were enrolled in the program, and by interviews with paren...

Background: Numerous hormonal changes and metabolic demands occur during pregnancy, resulting in complex maternal thyroid function. Thyroid disorder is the second most common endocrine found pregnancy next to diabetes group. It affects 1–2% of women reproductive age. Overt hypothyroidism complicates 0.3–0.5% pregnancies. The incidence subclinical pregnant about 2–3%. Hyperthyroidism present 0.1...

We experienced a case of fetal goitrous hypothyroidism in an infant delivered by a 33-year-old woman receiving 300 mg/day of propylthiouracil (PTU) for hyperthyroidism due to Graves' disease. A large fetal goiter (maximum diameter, 60 mm) was detected by magnetic resonance imaging (MRI) at 36 weeks of gestation. Initial fetal blood sampling revealed hypothyroidism with a serum thyroid-stimulati...

BACKGROUND Maternal thyroid function alters during pregnancy. Inadequate adaptation to these changes results in thyroid dysfunction and pregnancy complications. OBJECTIVES This prospective study aimed to evaluate the prevalence of thyroid diseases in pregnancy and its outcomes in south of Iran. MATERIALS AND METHODS This prospective study was conducted on 600 healthy singleton pregnant wome...

Maternal thyroid state is an important predictor of pregnancy outcome. Both hyperthyroidism and hypothyroidism have been shown to have an adverse impact on pregnancy. There is a wide range in the prevalence of thyroid dysfunction worldwide. In the USA which is considered an iodine replete country, 2%–3% of apparently healthy, non pregnant women of childbearing age have an elevated serum TSH wit...

Steroid hormones exert profound effects on the development of brain areas controlling complex cognitive function in adulthood. One class, progestins, may contribute by acting on the progestin receptor (PR), which is transiently expressed in a critical layer of developing cortex: the subplate. PR expression in the subplate coincides with the establishment of ongoing cortical connectivity and may...

Thyroid pathology worsens during pregnancy. Hypothyroidism can be pre-existent or may begin during pregnancy period. Most of the patients who presented hypothyroidism during pregnancy have a history of thyroid disease for which they have undergone treatment (medical, surgical or radioisotopes). Hypothyroidism is difficult to be diagnosed during pregnancy as the signs can belong to pregnancy its...

Objectives. Diabetes mellitus (DM) and hypothyroidism are each associated with increased rate of pregnancy complications. However, their combined morbidity during gestation is poorly studied. Therefore, the aims of this study were to determine the prevalence of the combined morbidity of DM & hypothyroidism and whether it is associated with adverse maternal and neonatal outcome. Study design. Th...

Thyroid disorder is a very common endocrine problem encountered by pregnant women. Maternal thyroid dysfunction associated with adverse outcome both in mother and fetus.
 The aim of the study: to find out prevalence various disorders women attending antenatal clinic.
 Materials methods. This prospective cross-sectional study was carried Department Obstetrics Gynecology, F.M. Medical C...

Maternal hypothyroidism impairs fetal growth in the rat, but the mechanisms by which this occurs are unknown. Since the fetus derives its glucose supply from the mother, and maternal thyroidectomy may disturb maternal and placental glucose metabolism, we postulated that maternal and/or placental glucose metabolic compromise may contribute to fetal growth retardation in hypothyroid dams. Feto-pl...