The methylation of a cytosine at the carbon 5 position (5meC) is a common epigenetic mark in eukaryotic cells that is normally found in CpG and CpHpG (H=A,C,T) sequence contexts. The inactivation of one of the X-chromosomes in female cells, the allele-specific expression of imprinted genes or the role in the embryonic development which is shown by the early lethality of Dnmt3a and Dnmt3b defici...

Jennette JC, Falk RJ: Autoimmunity is triggered by cPR-3(105–201), a protein complementary to human autoantigen proteinase-3. Nat Med 10: 72–79, 2004 8. Stegeman CA, Tervaert JW, de Jong PE, Kallenberg CG: Trimethoprim-sulfamethoxazole (co-trimoxazole) for the prevention of relapses of Wegener’s granulomatosis. Dutch Co-Trimoxazole Wegener Study Group. N Engl J Med 335: 16–20, 1996 9. Kain R, M...

[1] Long-term climate trends of surface air temperature should not be expected to have the same trends for light wind and stronger wind nights, even if the trends in the boundary layer heat fluxes were the same. Parker (2004) segmented observed surface temperature data into lighter and stronger wind terciles in order to assess whether the reported large-scale global-averaged temperature increas...

We define the Grothendieck group of an n-exangulated category. For n odd, we show that this shares many properties with exact or a triangulated In particular, classify dense complete subcategories category n-(co)generator in terms subgroups group. This unifies and extends results Thomason, Bergh–Thaule, Matsui Zhu–Zhuang for triangulated, $$(n+2)$$ -angulated, extriangulated categories, respect...

Background: IgG4-related disease (IgG4-RD) is an autoimmune disorder and frequently involve multiple organs. The respiratory tract one of the most involved sites. Objectives: This study aimed to compare demographic clinical characteristics (IgG4-RRD) non-IgG4-RRD patients in a large cohort. Methods: We carried out retrospective 452 cases IgG4-RD (104 IgG4-RRD 348 patients) diagnosed at Peking U...

There was considerable interest in the properties and the fate of heavy quarkonium states at finite temperature since the famous conjecture by Matsui and Satz [1]. It has been argued that color screening in medium will lead to quarkonium dissociation above deconfinement, which in turn can signal quark gluon plasma formation in heavy ion collisions. The basic assumption behind the conjecture by ...

Author’s response to critical essays by Brian Weatherson, Alex Byrne, and Stephen Yablo on Philosophical Analysis in the Twentieth Century, Volume 2

The objective of this study was to characterize the reproduction of Cichla kelberi in an artificial lake, located in the municipality of Leme, in the state of São Paulo, Brazil. Breeding occurred in spring, and summer. The L(50) and the L(100) of this species were 192 and 235 mm (L(50)), for males and females, respectively, and 290 mm (L(100)) for both sexes. Spawning was parceled. The oocytes ...