Drug discovery applies multidisciplinary approaches either experimentally, computationally or both ways to identify lead compounds to treat various diseases. While conventional approaches have yielded many US Food and Drug Administration (FDA)-approved drugs, researchers continue investigating and designing better approaches to increase the success rate in the discovery process. In this article...

In this paper we describe a morphological analysis method based on a maximum entropy model. This method uses a model that can not only consult a dictionary with a large amount of lexical information but can also identify unknown words by learning certain characteristics. The model has the potential to overcome the unknown word problem.

Image segmentation plays an important role in medical imaging applications. Therefore, accurate methods are needed for the successful segmentation of medical images for diagnosis and detection of various diseases. In this paper, we have used maximum entropy to achieve image segmentation. Maximum entropy has been calculated using Shannon, Renyi and Tsallis entropies. This work has novelty based ...

The metabolic network of a cell can be decomposed into discrete elementary modes that contribute, each with a certain probability, to the overall flux through the metabolism. These modes are cell function supporting, fundamental pathways that represent permissible ‘quantum’ states of the metabolism. For the case that cellular regulatory mechanisms for pathway fluxes evolved in an unbiased way, ...

A new variance formula is developed using the generalized inverse of an increasing function. Based on formula, a entropy for any uncertain variable provided. Most formulas in literature are special cases formula. Using maximum distribution unimodel variables provided without Euler–Lagrange equation.

Vertical soil moisture profiles based on the principle of maximum entropy (POME) were validated using field and model data and applied to guide an irrigation cycle over a maize field in north central Alabama (USA). The results demonstrate that a simple two-constraint entropy model under the assumption of a uniform initial soil moisture distribution can simulate most soil moisture profiles that ...

A new algorithm for computing the maximum entropy ranking over models is presented. The algorithm handles arbitrary sets of propositional defaults with associated strength assignments and succeeds whenever the set satisfies a robustness condition. Failure of this condition implies the problem may not be sufficiently specified for a unique solution to exist. This work extends the applicability o...