Melanoma is an aggressive malignancy that frequently spreads to the brain, resulting in rapid deterioration in both quality and quantity of life. Historically, treatment options for melanoma brain metastases (MBM) have predominantly consisted of surgery and radiotherapy. While these options can help provide local control, the majority of patients still develop intracranial progression. Indeed, ...

To assess the efficiency of pea roots to mobilize available phosphorus (P) from P compounds we subjected various pea genotypes to a post-treatment method. Axenic seedlings were raised on P-deficient semisolid synthetic medium using control blanks without a plant otherwise treated in the same way. AlPO(4), CaHPO(4), FePO(4), apatite and meat-bone-meal (MBM) were tested. A genotype was tested fro...

Although bovine spongiform encephalopathy (BSE) has occurred in other European countries, the major epidemic has been in the United Kingdom (UK), where there have been more than 163,000 cases so far. BSE has been linked to the practice of feeding meat-and-bone meal (MBM), putatively contaminated with scrapie agent, to cattle. A ban on the feeding of MBM to ruminants in the UK has resulted in a ...

Memory impairments of DBA/2J mice have been frequently reported in spatial and emotional behavior tests. However, in some memory tests involving food reward, DBA/2J mice perform equally well to C57BL/6J mice or even outperform them. Thus, it is conceivable that motivational factors differentially affect cognitive performance of different mouse strains. Therefore, spatial memory of DBA/2J and C5...

INTRODUCTION Few literatures have studied the blood management in patients treated with staged bilateral primary total knee arthroplasty (TKA) in a single hospitalization period. Therefore, this study aims to evaluate the effectiveness and safety of the newly introduced multimodal blood management (MBM) in these patients. MATERIALS AND METHODS We retrospectively compared the perioperative par...

We report the discovery of a spatially-resolved edge-on protoplanetary disk in the ∼2-Myr-old MBM 12 young association. Our near-infrared images of LkHα 263C (MBM 12A 3C), obtained with the Hokupa’a adaptive optics system on the Gemini North telescope, clearly show two elongated reflection nebulosities separated by a dark lane, a morphology well-matched by scattered light models of an optically...

Brain metastases are a common and serious complication among patients with metastatic melanoma. The selective BRAF inhibitor vemurafenib has demonstrated clinical efficacy in patients with BRAF V600E-mutant melanoma brain metastases (MBM). We examined the real-world application and clinical outcomes of vemurafenib in this patient population. Demographic, treatment patterns, response, and surviv...

PURPOSE The aim of this study was to experimentally assess the dosimetric impact of leaf interdigitation using different inverse treatment strategies for representative tumour sites and to identify the situations in which leaf interdigitation can benefit these tumour sites. MATERIAL AND METHODS Sixty previously treated patients (15 nasopharyngeal carcinoma (NPC), 15 multiple brain metastasis ...

IMPORTANCE The treatment of multiple brain metastases (MBM) from melanoma is controversial and includes surgical resection, stereotactic radiosurgery (SRS), and whole-brain radiation therapy (WBRT). Several new classes of agents have revolutionized the treatment of metastatic melanoma, allowing some subsets of patients to have long-term survival. Given this, management of MBM from melanoma is c...

We report results of a sensitive search for cold dust and molecular gas in the disks around 8 T Tauri stars in the high-latitude cloud MBM 12. Interferometric observations of 3 mm continuum emission in 5 fields containing 6 of the objects, and literature values for the remaining two, limit the disk masses to Mdisk < 0.04–0.09 M⊙ (gas+dust), for a gas:dust mass ratio of 100 and a distance of 275...