OBJECTIVE(S) Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards Fe(III)-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide. In this paper the results of a comparative study on the SLO inhibitory activities of the m...

In the present investigation a reverse phase high performance liquid chromatographic method and a visible spectrophotometric method were developed for the quantitative determination of meropenem, a highly active antibiotic in powder for injection. The chromatographic analysis was carried out by reversed phase technique on an ultra sphere XL-ODS, 75mm x 4.6mm I.D.,5μm column with a mobile phase ...

Two simple, rapid and accurate spectrophotometric and spectrofluorimetric methods developed for the determination of Tofisopam (TF) in pure form and in pharmaceutical formulation. The spectrophotometric method (A) is based on the reduction of ferric into ferrous in presence of 1, 10-phenanthroline to give an orange –red colored ferroin complex measured at 510 nm. Method (B) spectrofluorimetric ...

Objective(s): Allylbenzenes have been recently developed as inhibitors of lipoxygenases. They decrease peroxidation activity via mimicking 1,4-unsaturated bonds of fatty acids by their allyl portion. We designed and synthesized new derivatives of allyl benzenes (6a-f) with isopropoxy and amide substituents at ortho and meta positions towards allyl group, respectively. ...

  Objective(s): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards FeIII-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide. In this paper the results of a comparative study on the SLO inhibitory activities of the ...

Taxadiene synthase (TDS) is the rate-limiting enzyme of Taxol biosynthesis that cyclizes geranylgeranyl pyrophosphate into taxadiene. Attenuating productivity by fungi main challenge impeding its industrial application; it possible silencing expression TDS most noticeable genomic feature associated with Taxol-biosynthetic abolishing in fungi. As such, characterization unique biochemical propert...