نتایج جستجو برای: mda
تعداد نتایج: 20691 فیلتر نتایج به سال:
BACKGROUND Mass drug administration (MDA) with azithromycin, carried out for the control of blinding trachoma, has been linked to reduced mortality in children. While the mechanism behind this reduction is unclear, it may be due, in part, to improved nutritional status via a potential reduction in the community burden of infectious disease. To determine whether MDA with azithromycin improves an...
We presently demonstrate that histone deacetylase inhibitors (HDACIs) enhance toxicity of melanoma differentiation-associated gene-7/interleukin 24 (mda-7/IL-24) in invasive primary human glioblastoma multiforme (GBM) cells. Additionally, a method is described to augment the efficacy of adenoviral delivery of mda-7/IL-24 in these cells. HDACIs synergized with melanoma differentiation-associated...
Relationship among malondialdehyde (MDA), 2-thiobarbituric acid (TBA)-reactive substances (TBA-RS), and tocopherols in the oxidation of rapeseed oil was investigated. MDA was determined by a new HPLC method with chemical derivatization. When the oil was heated at 170 degrees C, TBA-RS and MDA increased. The contents of TBA-RS were approximately 1.6 times higher than those of MDA. Correlation be...
The human Ca2+-activated chloride channel-2 (CLCA2) is expressed in normal breast epithelium but not in breast tumors of different stages of progression. Northern analysis of nontransformed and transformed breast epithelial cell lines revealed CLCA2 expression in the nontransformed cell line MCF10A and the nontumorigenic cell line MDA-MB-453, whereas all tumorigenic cell lines were negative (MD...
BACKGROUND Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases. Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA). SUBJECTS AND METHODS We measured MDA levels in EBC in a large number of patients (N = 194) with respiratory diseases: asthma (N = 64), bron...
In a recent article in this journal (1), a limited number of papers dealing with variations of malondialdehyde (MDA) in different pathological conditions were reviewed. After a brief introduction on the importance of oxidative stress, MDA production pathways, and analytical techniques, Singh et al. (1) concluded as " MDA is a useful bi-omarker for lipid peroxidation and oxidative stress. " The ...
BACKGROUND Patients with psoriatic arthritis (PsA) experience functional impairment and reduced quality of life, and thus patient global assessment in PsA is explained mainly by the physical, but also by the psychological, aspect of the disease. To assess the prevalence of minimal disease activity (MDA) in Spanish patients with PsA, we examined their characteristics and the association between ...
BACKGROUND This study employed various monitoring methods to assess the impact of repeated rounds of mass drug administration (MDA) on bancroftian filariasis in Papua New Guinea, which has the largest filariasis problem in the Pacific region. METHODOLOGY/PRINCIPAL FINDINGS Residents of rural villages near Madang were studied prior to and one year after each of three rounds of MDA with diethyl...
امروزه فلزات سنگین به یکی از خطرناک ترین مسائل زیست محیطی جهانی تبدیل شده اند. آلودگی فلزات سنگین در اکوسیستم های آبی بر ریزجلبک ها و زوپلانکتون ها تأثیر گذار است، بیومس و فراوانی گونه ها را تغییر داده و روابط درون گونه ای را به سمت غالبیت گونه های کمتر حساس به پیش می برد. در این تحقیق اثر تنش کوتاه مدت غلظت های مختلف فلز سنگین کادمیم بر دو میکرو آلگ سیانوباکتری anabaena sp. و جلبک سبز chlorell...
مقدمه و هدف: صرع ژنرالیزه بیماری مزمنی است که مشخصه آن حملات مکرر تشنج است و می تواند محتوای رادیکال های آزاد اکسیژن و انواع سوپراکسیدها را در مغز افزایش دهد. هدف از مطالعه حاضر ارزیابی سطح مالونیل دی آلدهید(به عنوان شاخص استرس اکسیداتیو) در پلاسمای بیماران صرع دو استان مهم کشور یعنی البرز و اردبیل است. مواد و روش: 120 نفر از بیماران صرعی مراجعه کننده به درمانگاه های نورولوژی در محدوده سنی 40-2...
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