The Model Driven Architecture (MDA) of the Object Management Group (OMG) represents an approach of software development based on the use of models. The transformation of models is at the heart of the MDA (Model-Driven Architecture) approach. CIM to PIM transformation can be of a great support for domain experts and business analysts, but is not mentioned enough by OMG. Thus, we have decided to ...

In a recent article in this journal (1), a limited number of papers dealing with variations of malondialdehyde (MDA) in different pathological conditions were reviewed. After a brief introduction on the importance of oxidative stress, MDA production pathways, and analytical techniques, Singh et al. (1) concluded as " MDA is a useful bi-omarker for lipid peroxidation and oxidative stress. " The ...

Benign prostate hypertrophy (BPH) is the most common benign tumor in men due to obstruction of the urethra and, finally, uremia. Malondialdehyde (MDA) is a product derived from peroxidation of polyunsaturated fatty acids and related esters. Evaluation of MDA in serum represents a non-invasive biomarker of oxidative stress. Prostate-specific antigen (PSA) is a sensitive marker for prostatic hype...

Information system’s models on higher level of abstraction have become a daily routine in many software companies. The concept of Model Driven Architecture (MDA) published by standardization body OMG since 2001 has become a concept for creation of software applications and information systems. MDA specifies four levels of abstraction: top three levels are created as graphical models and the las...

Objective : Oral squamous cell carcinoma (OSCC) is considered to be a serious life threatening issue for almost two decades. The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of oral cancer. Methods : Lipid peroxidation and antioxidant status in OSCC patients were estimated an...

Pregnancy-induced hypertension (PIH) is a common medical complication of pregnancy with a high incidence. The study comprised of 30 normal and 30 PIH cases in their third trimester of pregnancy and the following estimations were done: Serum Malondialdehyde level (MDA), Vitamin E, triglycerides (TG), total cholesterol (TC), HDL-cholesterol (HDL-C) and LDL-C. The PIH cases had significant rise in...

BACKGROUND HIV and TB infections are both associated with elevated oxidative stress parameters. Anti-oxidant supplementation may offer beneficial effects in positively modulating oxidative stress parameters in HIV and HIV-TB infected patients. We investigated the effects of vitamin A and C supplementation on oxidative stress in HIV infected and HIV-TB co-infected subjects. METHODS 40 HIV/TB c...

Dysfunction of endothelial cells in severe malaria may result from excessive activation of tumor necrosis factor (TNF)-α which leads to an increase in production of reactive oxygen species (ROS) and decrease of antioxidant level of endothelial cells. To investigate the effect of N-acetylcysteine (NAC) on hydrogen peroxide (H2O2), malondialdehyde (MDA) and glutathione (GSH) levels produced by en...

(+/-)-3,4-Methylenedioxyamphetamine (MDA), an amphetamine analog with hallucinogenic activity, produced selective long-lasting reductions in the level of serotonin, the number of serotonin uptake sites, and the concentration of 5-hydroxyindoleacetic acid in rat brain. Morphological studies suggested that these neurochemical deficits were due to serotonin nerve terminal degeneration. These resul...

abstract background and objective: it has been shown that oxidative stress increases in diabetes and it has an important role in its development and subsequent complications. thus, the aim of this study was to investigate the effect of acute resistance exercise on oxidative stress in skeletal muscle and cardiac tissues of streptozotocin-induced diabetic rats. materials and methods: twenty male ...