Platelets play roles in both thrombosis and inflammation, and chemokines that are released at sites of inflammation could potentially activate platelets. Among the chemokine receptors expressed on platelets, the CXCR4 is the receptor for chemokine stromal cell-derived factor-1 (SDF-1), and the CCR4 is the receptor for macrophage-derived chemokine (MDC). Of the chemokines tested, SDF-1 and MDC w...

BACKGROUND Multidisciplinary care (MDC) of heart failure (HF) can significantly reduce rates of unplanned hospitalisation, the major cost component of HF care. AIMS This prospective, randomised, controlled study examines the cost-benefits of MDC of HF in the setting of optimal medical care. METHODS 98 NYHA class IV HF patients (mean age 70.8+/-10.5 years) were randomised to MDC (n=51) or ro...

Chronic hepatitis B virus (HBV) infection is the result of an inadequate immune response towards the virus. Myeloid dendritic cells (mDC) of patients with chronic HBV are impaired in their maturation and function, resulting in more tolerogenic rather than immunogenic responses, which may contribute to viral persistence. The mechanism responsible for altered mDC function remains unclear. The HBV...

OBJECTIVES We analyzed the frequency of myeloid dendritic cell (mDC) and plasmacytoid dendritic cell (pDC) precursors in blood of patients with coronary artery disease (CAD) and in atherosclerotic carotid plaques of patients with cerebrovascular disease (CVD). BACKGROUND Circulating DC precursors are reduced in several autoimmune diseases. Atherosclerosis has features of an autoimmune disease...

Este estudio se centra en la Movilización Del Conocimiento (MDC) y su vinculación el contexto de investigación inclusiva. Metodológicamente, trabajo desarrolla desde un enfoque cualitativo-descriptivo para identificar conceptualización del término, los condicionantes, roles, estrategias procesos intragrupales que grupo investigadores trabajan educación Tras realización focal con estos indagar s...

Imagery classification has long been used in analyzing remote sensing data. The use of the algorithm model can affect results interpreting benthic habitats shallow water. This study aimed to determine best for mapping habitat cover through Sentinel-2 satellite imagery. Three models were employed: Maximum Likelihood Classification (MLC), Minimum Distance (MDC), and Mahalanobis (MaDC). types extr...

PURPOSE We have reported that calcitonin gene-related peptide gene-transfected mature dendritic cells (mDC) suppress murine experimental autoimmune optic neuritis (EAON) and experimental autoimmune encephalitis (EAE) via interleukin-10 (IL-10) production. In our study, we examined whether IL-10-transfected mDC prevent development of EAON and EAE. METHODS A plasmid expressing mouse IL-10 was c...

Upon treatment with vesicular stomatitis virus (VSV) particles, plasmacytoid dendritic cells (pDC) are triggered to mount substantial type I IFN responses, whereas myeloid DC (mDC) are only minor producers. Interestingly, bone marrow-derived (BM-)mDC were more vulnerable to infection with enhanced GFP (eGFP)-expressing VSV (VSVeGFP) than BM-pDC. BM-pDC stimulated with wild-type VSV mounted TLR-...

In the March 2007 issue of JASN, Hemmelgarn et al.1 reported a 50% reduction in the risk for all-cause mortality for patients who had chronic kidney disease (CKD) and attended multidisciplinary care (MDC) clinics compared with those who received usual care. Their survival curves showed a clear divergence in rates of death between the two groups in the first 6 mo of follow-up. We suggest that it...

Numerical and functional deficits in myeloid (mDC) and plasmacytoid dendritic cell (pDC) subsets have been found in both adult and pediatric HIV-1 carriers. Whether these impaired DC subsets can be restored after treatment with highly active antiretroviral therapy (HAART) is currently unknown, especially in HIV-1-infected children. In this report, we characterized mDC and pDC subsets in 18 HIV-...