The tumor suppressor p53 is a labile protein whose level is known to be regulated by the Mdm-2-ubiquitin-proteasome degradation pathway. We have found another pathway for p53 proteasomal degradation regulated by NAD(P)H quinone oxidoreductase 1 (NQO1). Inhibition of NQO1 activity by dicoumarol induces p53 and p73 proteasomal degradation. A mutant p53 (p53([22,23])), which is resistant to Mdm-2-...

The editor-in-chief, deputy editor, associate editors, editorial board, and staff of Medical Decision Making and MDM Policy & Practice, the official journals of the Society for Medical Decision Making, acknowledge and thank the following people for their assistance in reviewing manuscripts during 2016. The journals’ success rests in large measure on the quality and promptness of the reviews it ...

The armadillo could be considered as an experimental model for leprosy studies. Mycobacterium leprae main host cells are macrophages and Schwann cells. However, endocytosis and germicidal activities of armadillo macrophages and monocytes have not yet been evaluated. The aim of this research was to evaluate endocytosis and NBT-reduction activities of monocyte-derived macrophages (MDM) and monocy...

A miniaturized new topology of the planar monopole antenna using a Magneto-Dielectric Material (MDM) is proposed in this paper. The element realized by introducing slots partially covered MDM. We optimized and modified MDM dimensions to enhance impact material on antenna, including its structure. This shows miniaturization rate 60% antenna’s height (51 cm 20 cm) covering only 5% surface measure...

Monocyte-derived macrophages (MDM) are widely distributed in all tissues and organs, including the central nervous system, where they represent the main part of HIV-infected cells. In contrast to activated CD4(+) T lymphocytes, MDM are resistant to cytopathic effects and survive HIV infection for a long period of time. The molecular mechanisms of how HIV is able to persist in macrophages are no...

Lung macrophages are an important defence against respiratory viral infection and recent work has demonstrated that influenza-induced macrophage PDL1 expression in the murine lung leads to rapid modulation of CD8+ T cell responses via the PD1 receptor. This PD1/PDL1 pathway may downregulate acute inflammatory responses to prevent tissue damage. The aim of this study was to investigate the mecha...

The original topological Aharonov-Casher (AC) effect is due to the interaction of the anomalous magnetic dipole moment (MDM) with certain configurations of electric field. Naively one would not expect an AC effect for a scalar particle for which no anomalous MDM can be defined in the usual sense. In this letter we study the AC effect in supersymmetric systems. In this framework there is the pos...

 Abstract—Mode division multiplexing (MDM) has the potential of increasing the capacity of optical fiber transmission system. However, primary impaired factor mode-dependent loss (MDL) poses fundamental performance limitations. Recently MIMO space time coding technique has provided a potential solution to mitigate the MDL and hence started receiving considerable interests. In this paper, ortho...

Neuronal damage in human immunodeficiency virus type 1 (HIV-1) infection in the brain is thought to occur at least in part through NMDA receptor (NMDAR) excitation initiated by soluble neurotoxins from HIV-infected brain macrophages. Furthermore, brain regions enriched in NMDAR-2A (NR2A) and NMDAR-2B (NR2B) subunits, such as the hippocampus, are particularly vulnerable. Using cultured rat hippo...

Magnesium (Mg) has drawn increasing attention as a tissue engineering material. However, there have been very few studies of laser-melted Mg-Zn alloys. In this study, four binary Mg-xZn (x = 2, 4, 6 and 8 wt. %) alloys were fabricated by laser melting. The influence of zinc (Zn) content and technique on the degradation behavior and mechanical properties of Mg were discussed. Results revealed th...