OBJECTIVE To determine the multidrug-resistant transporter (MDR) activity in oocytes and their potential role in oocyte susceptibility to chemotherapy. DESIGN Experimental laboratory study. SETTING University and academic center for reproductive medicine. SUBJECT(S) Women with eggs retrieved for intracytoplasmic sperm injection cycles and adult female FVBN and B6C3F1 mouse strains. INTE...

The large amount of repeats, especially high copy repeats, in the genomes of higher animals and plants makes whole genome assembly (WGA) quite difficult. In order to solve this problem, we tried to identify repeats and mask them prior to assembly even at the stage of genome survey. It is known that repeats of different copy number have different probabilities of appearance in shotgun data, so b...

OBJECTIVE To study the safety and efficacy of a cholinesterase inhibitor, donepezil hydrochloride, for the treatment of dementia in Parkinson's disease (PD). METHODS This was a randomised double blind, placebo controlled, crossover study in 22 subjects with PD and dementia. Participants were randomised to receive either donepezil followed by identical placebo, or placebo followed by donepezil...

Energy transfer experiments are carried out at dilute concentrations of donors ~10 M , coumarine 334! and acceptors ~5310 M , sulforhodamine 101! in a levitated microdroplet ~diameter, 2a519 mm!, using an aerosol particle fluorescence microscope. Microphotographs in donor and acceptor luminescence show that the transfer mechanism is not of a Förster type, but is mediated by morphology dependent...

OBJECTIVE To evaluate the effectiveness of the maternal death review (MDR) system and process in improving quality of maternal and newborn health care in northern Nigeria. METHODS A combination of quantitative and qualitative methods was used, including review of MDR forms and of health management information system data on maternal deaths (MDs), as well as semi-structured interviews with mem...

BACKGROUND Recent research has shown evidence of disproportionate time allocation for patient communication during multidisciplinary rounds (MDRs). Studies have shown that patients discussed later during rounds receive lesser time. OBJECTIVE The aim of our study was to investigate whether disproportionate time allocation effects persist with the use of structured rounding tools. METHODS Usi...

the y-core conditions in L j have to be satis-ed. Note that there is a subtle issue here. As deened, an embedding of L i tests the conditions of remote markers on which local markers depend. However, it is not forced to choose the same value for the remote marker as would a local embedding of the remote LDRS choose. This is so in order to allow for remote anaphoric references even in case the w...

Background: Prostate cancer screening is more commonly utilized by highly educated people. As shown by marginalization-related diminished returns (MDRs), the effects of socioeconomic status (SES) such as education on the health outcomes are considerably smaller for ethnic minorities than for Whites. The role of MDRs as a source of ethnic health disparities is, however, still un...

Abstract A greenhouse microcosm study investigated the impacts of recovered iron oxyhydroxide mine drainage residuals (MDRs) on phosphorus (P) and trace metal distributions at sediment layer/water column interface in Grand Lake o’ Cherokees, a large reservoir receiving waters impacted by both historic mining current agricultural land uses. Each mesocosm included 5 kg lake 20 L on-site groundwat...