We evaluated the influence of an antioxidant and zinc nutritional supplement [the Age-Related Eye Disease Study (AREDS) formulation] on delaying or preventing progression to neovascular AMD (NV) in persons with age-related macular degeneration (AMD). AREDS subjects (n = 802) with category 3 or 4 AMD at baseline who had been treated with placebo or the AREDS formulation were evaluated for differ...

In recent years, we have studied information properties of various types of mixtures of probability distributions and introduced a new type, which includes previously known mixtures as special cases. These studies are disseminated in different fields: reliability engineering, econometrics, operations research, probability, the information theory, and data mining. This paper presents a holistic ...

Consider the problem of sequentially testing which of two normally distributed treatments has a larger mean response. A Bayesian formulation of this problem, where the treatment means have conjugate priors, is used. If we restrict our attention to the class of procedures using the Kiefer and Sacks stopping time then we will not exceed the minimum Bayes risk by more than the cost of a fixed numb...

In this paper we introduce a natural image prior that directly represents a Gaussiansmoothed version of the natural image distribution. We include our prior in a formulation of image restoration as a Bayes estimator that also allows us to solve noise-blind image restoration problems. We show that the gradient of our prior corresponds to the mean-shift vector on the natural image distribution. I...