BACKGROUND Inexpensive medicines with a long history of use may currently be prescribed off-label for rare indications. Reimbursement is at the discretion of health insurance companies, and may be unpredictable. The example addressed was ephedrine as add-on treatment for myasthenia gravis. Stakeholders from academia, a patient organization, the Dutch National Health Care Institute (NHCI) and Du...

Alpha-dystroglycanopathies are a clinically and genetically heterogenous group of muscular dystrophies characterized by the reduced or absent glycosylation of alpha-dystroglycan (Muntoni et al., 2002). The hypoglycosylation of alpha-dystroglycan leads to decreased binding of its ligands, including laminin, agrin and perlecan in skeletal muscle and neurexin in the brain. The only known target fo...

Alpha-dystroglycanopathies are a clinically and genetically heterogenous group of muscular dystrophies characterized by the reduced or absent glycosylation of alpha-dystroglycan (Muntoni et al., 2002). The hypoglycosylation of alpha-dystroglycan leads to decreased binding of its ligands, including laminin, agrin and perlecan in skeletal muscle and neurexin in the brain. The only known target fo...

The aniline dimer, N-(4-aminophenyl)aniline has been polymerized cleanly under mild conditions to obtain an emeraldine base form of polyaniline using [MeB(3-(Mes)Pz)3]CuCl as the catalyst and H2O2 as the oxidant, while the subsequent acidification of the emeraldine base gives the conducting emeraldine salt form of polyaniline.

Tiwai onion contains secondary metabolic compounds of phenol, alkaloid, terpenoid, and has antioxidant antimicrobial bioactivity. The tiwai can be used for supplement drinks. purpose this study was to obtain the best treatment extract drinks on malondialdehyde levels in mice (Mus musculus L.). This a completely randomized design with one factor consisting 8 treatments: 1) new oil (mb) as contro...

This work presents a static analysis technique based on program slicing for CSP specifications. Given a particular event in a CSP specification, our technique allows us to know what parts of the specification must necessarily be executed before this event, and what parts of the specification could be executed before it in some execution. Our technique is based on a new data structure which exte...

In recent years, augmented reality(AR) technology has gained much attention due to its disruptive and revolutionary nature. Thanks the advanced nano‐imprint lithographic technique, diffractive waveguide based display becomes research hotspot. There are three main types of including one dimension grating, two volume holography. this paper, we proposed that slant grating is used as in‐coupling ou...

The novel amino(imino)germylene 1 was prepared by the conversion of HNIPr (NIPr = bis(2,6-diisopropylphenyl)imidazolin-2-imino) with 1 equiv. of Ge[N(SiMe3)2]2. Germylene 1 reacts with B(C6F5)3 to afford the borate salt 2(+)[MeB(C6F5)3](-) in a methyl-abstraction and ring-closing reaction. The conversion of 2 with Fe2(CO)9 furnishes the germylene iron carbonyl complex 3 with a trigonal planar-c...

V. Sautter, A. Jambon and O. Boudouma. Laboratoire de Minéralogie, Muséum National d’Histoire Naturelle, CNRS UMR 7160, 61 rue Buffon , 75005 Paris, France (vsautter @mnhn.fr), 2 Laboratoire Magie, UMR 7047, Université P. et M. Curie Paris VI, case 110, 4 place Jussieu, 75252 Paris cedex 05, France ([email protected]), 3 Service MEB UFR 928, Université P. et M. Curie Paris VI, 4 place Juss...