Depression is one of the most frequent and severe mental disorder. Since the discovery of antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds, several classes of psychotropic drugs have shown be effective in treating major depressive disorder (MDD). However, there is a wide range of variability in response to ADs that might lead to non response or partia...

The anti-oestrogen tamoxifen is the most commonly used treatment for patients with oestrogen-receptor (ER)-positive breast cancer. Although many patients benefit from tamoxifen in the adjuvant and metastatic settings, resistance is an important clinical problem. The target of tamoxifen in vivo is the ER. Over the last decade many advances have been made in our understanding of the biology of th...

Progress of research into the problem of resistance to antibiotics is held back by lack of knowledge of the biochemical mechanisms by which these drugs act. Fortunately, it is possible to study some of the mechanisms of drug resistance, even at a biophysical or biochemical level, without necessarily knowing very much about how the drug works—just as it is possible to study (at least at a biolog...

There is no doubt that antimicrobial agents have saved the human race from a lot of suffering due to infectious disease burden. Without antimicrobial agents, millions of people would have succumbed to infectious diseases. Man has survived the accidental wrath of microorganisms using antimicrobial agents and other mechanisms that keep them at bay. Hardly years after the discovery and use of the ...