Leigh Ellis and Massimo Loda Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263; Department of Medical Oncology, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana–Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, MA 02115...

From the Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Medical School, Mayo Clinic, Rochester, MN (L.W., R.M.W.); and the UNC Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill (H.L.M). Address reprint requests to Dr. Weinshilboum at the Division of Clinical Pharmacology, Department o...

1 Center for Cancer Systems Biology (CCSB), and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA, 2 Department of Genetics, Harvard Medical School, Boston, MA, USA and 3 Proteostasis Therapeutics, Inc., Cambridge, MA, USA * Corresponding author. Proteostasis Therapeutics, Inc., 200 Technology Square, Suite 402, Cambridge, MA 02139, USA. Tel.: þ 1 617 582 9114; Fax: þ ...

Andre Terzic, Russell L. Moore, and Scott A. Waldman Marriott Heart Disease Research Program, Divisions of Cardiovascular Diseases and Clinical Pharmacology, Departments of Medicine, Molecular Pharmacology and Experimental Therapeutics, and Medical Genetics, Mayo Clinic, Rochester, Minnesota; Department of Integrative Physiology and Regent Administrative Center, University of Colorado, Boulder,...

background: â  advanced hepatic fibrosis and cirrhosis has generally been considered to be irreversible. the aim of this study was to determine whether cirrhosis is reversible.â  â  methods: â  seven patients with autoimmune hepatitis with histologic evidence of cirrhosis were enrolled. after treatment, they had follow-up liver biopsy while in clinical and biochemical remission. biopsy specimen...

1 Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China, 2 Graduate School of Peking Union Medical College, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 3 Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics, The Chinese University of Hon...

1 Hannover Medical School, Institute of Cellular Therapeutics, Hannover, Germany, 2 Institute of Clinical Immunology, University Hospital and Medical Faculty, University of Leipzig, Leipzig, Germany, 3 Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany, 4Institut National de la Santé et de la Recherche Médicale (INSERM) U1160; Université Paris Diderot, Sorbonne Paris Cité, P...