Medicinal chemistry depends on many other disciplines ranging from organic chemistry andpharmacology to computational chemistry. Typically medicinal chemists use the moststraightforward ways to prepare compounds. The validation of any design project comes from thebiological testing.Studies of the binding site of vinblastine by a single cross—linking experiment identified it asbeing between resi...

Chemistry Central is a new open access website for chemists publishing peer-reviewed research in chemistry from a range of open access journals. A new addition, Chemistry Central Journal, will cover all of chemistry and will be broken down into discipline-specific sections, and Im delighted that Medicinal Chemistry will be a key discipline in this new journal.

In this paper we report the synthesis of three families of new amidine–based aromatic derivatives as potential DNA minor groove binding agents for the treatment of cancer. The preparation of mono–guanidine, mono–2–aminoimidazoline and asymmetric diphenyl guanidine/2–aminoimidazoline derivatives (compounds 1a,b,c to 8a,b,c) is presented. The affinity of these substrates and of a family of mono– ...

On December 2, 2004, the Society for Medicines Research held the seventh Trends in Medicinal Chemistry one-day meeting. The meeting brought together speakers from Europe representing both academia and industry and provided an overview of some of the latest approaches being taken in a range of therapeutic areas such as oncology, antiinfectives, CNS disease and reproductive medicine.

The beginning of modern drug research in India can be traced to early part of the twentieth century. Dr Upendra Nath Brahmachari worked on drugs for kala-azar at the Campbell Medical College, Calcutta. Colonel Ram Nath Chopra organized an active centre of research on the Indian medicinal plants at the School of Tropical Medicine, Calcutta. The lead given by Chopra led to start of investigations...

The paper investigates the relevance of medicinal chemistry for family planning and birth control by means of contraception. It discusses hormonal and non-hormonal methods and draws attention to the two central aspects of contraception, namely efficacy and safety of contraceptive methods.