Human pigmentation can be a risk factor for multiple diseases of the skin and eyes. Pigmentation in eyes is consequence differing amounts eumelanin pheomelanin, which have anti-oxidant pro-oxidant properties, respectively. Substantial work has established importance melanin synthesis blocking DNA damage from ultraviolet radiation (UV); however, there are associated with (e.g., acral lentignous,...

Skin pigmentation ensures efficient photoprotection and relies on the pigment melanin, which is produced by epidermal melanocytes transferred to surrounding keratinocytes. While molecular mechanisms of melanin synthesis transport in are now well characterized, much less known about transfer processing within Over past few decades, distinct models have been proposed explain how occurs at cellula...

BACKGROUND To assess the effect of smoking on lip and gingival pigmentation and also to assess the relationship of pigmentation with periodontal parameters. MATERIALS AND METHODS 109 smokers and an equal number of control subjects who were nonsmokers in the age range of 35 - 44 years comprised the study sample. All the participants were assessed for pigmentation on lip and gingiva and a total...

Status of individual animals is often shown in pigmentation. For instance, stress responsiveness is associated with melanin-based pigmentation in vertebrates in general. This pattern is evident in Atlantic salmon (Salmo salar) and rainbow trout (Onchorhynchus mykiss) with melanin-based spots indicating stress coping style. Arctic charr (Salvelinus alpinus) differ from other salmonids in pigment...

Skin pigmentation is a major feature of skin, and marker associated with beauty, health aging. Among the past genome-wide association studies on skin pigmentation, relatively small proportion have focused Chinese population. Large-scaled based measured phenotypes are particularly rare in other East Asian populations. In Jidong cohort study (N = 3,544), we low-exposed area colorimeter performed ...

More than 127 loci are actually known to affect pigmentation in mouse when they are mutated. From embryogenesis to transfer of melanin to the keratinocytes or melanocytes survival, any defect is able to alter the pigmentation process. Many gene mutations are now described, but the function of their product protein and their implication in melanogenesis are only partially understood. Each geneti...

One of the most striking phenomena in human oncology is the transformation of the normal skin color to an intense blue-gray pigmentation. This occurs as a complication of malignant melanoma. In the recent literature, several excellent examples of this type of pigmentation have been reported in patients with malignant melanoma. In this paper we report on another patient with generalized melanin ...

Excessive gingival pigmentation is a major esthetic concern for many people. The gingiva an important intraoral tissue which when affected particularly by mainly responsible the unpleasant appearance. A harmonious smile accounts perfect balance between pink and white component of oral cavity. It affects confidence, self-esteem, esthetics individual, can also have psychological impact on them. M...

Internal organs of ectotherms have melanin-containing cells that confer different degrees of coloration to them. Previous experimental studies analyzed their developmental origin, role in immunity, and hormonal regulation. For example, melanin increases with ultraviolet radiation (UV) and temperature in frogs and fish. However, little is known about how environmental variables influence the amo...

Since its use was first reported by 8rowne and Hogerzeil in 1962 ('0. /I), 8663, a synthesized phenazine dye, has proven to be an effective drug in the treatment of human leprosy and its use has become worldwide ( 2.7.9 " . 26. 3~. 39. 52. 5.1 ). The most significant and frequent side effect of this compound is an abnormal skin coloration. This can be divided into two types. One is an initial r...