Vaccine efficacy depends on strong long-term development of immune memory and the formation of memory CD8(+) T cells is critical for recall responses to infection. Upon antigen recognition by naïve T cells, the strength of the TcR signal influences the subsequent effector and memory cells differentiation. Here, we have examined the role of Itk, a tyrosine kinase critical for TcR signaling, in C...

Influence of response prepotency strength, general working memory resources, and specific working memory load on the ability to inhibit predominant responses: A comparison of young and elderly participants. Brain and Cognition (in press). Abstract One conception of inhibitory functioning suggests that the ability to successfully inhibit a predominant response depends mainly on the strength of t...

Adaptive memory requires context-dependent control over how information is retrieved, evaluated and used to guide action, yet the signals that drive adjustments to memory decisions remain unknown. Here we show that prediction errors (PEs) coded by the striatum support control over memory decisions. Human participants completed a recognition memory test that incorporated biased feedback to influ...

The ability to retain multiple items in short-term memory is fundamental for cognition, yet almost nothing is known about its neural basis. To explore the mechanisms underlying this ability, we trained two monkeys to remember a sequence of two images across a short delay. We then recorded the activity of neurons from the lateral prefrontal cortex during task performance. We found that the major...

Functional plasticity at cortical synapses and neurons is presumably associated with learning and memory. Additionally, coordinated refinement between glutamatergic and GABAergic neurons occurs in associative memory. If these assumptions are present, neuronal plasticity strength and learning efficiency should be correlated. We have examined whether neuronal plasticity strength and learning effi...

Memory based learning keeping full memory of learning material appears a viable approach to learning nlp tasks and is often superior in generalisation accuracy to eager learning approaches that abstract from learning mate rial Here we investigate three partial memory based learning approaches which remove from memory speci c task instance types estimated to be exceptional The three approaches e...

Synaptic plasticity in the central nervous system (CNS) of mammals has been discussed for many years. Several forms of synaptic plasticity of mammal’s CNS have been identified, such as those that occur in long-term potentiation (LTP). Different types of LTP have been observed in distinctive areas of the CNS of mammals. The hippocampus is one of the most important areas in the CNS that pla...