For the first incumbent operator it is very important to understand how to react when the second operator comes to the market. In this paper which is prepared for preliminary study of GSM market in Iran, we have studied five MENA markets according to the similarity point of view. This paper aims at analyzing the impact of second entrants in selected markets on certain marketing key performance ...

BACKGROUND It is perceived that little is known about the epidemiology of HIV infection among people who inject drugs (PWID) in the Middle East and North Africa (MENA). The primary objective of this study was to assess the status of the HIV epidemic among PWID in MENA by describing HIV prevalence and incidence. Secondary objectives were to describe the risk behavior environment and the HIV epid...

Purpose – The purpose of this paper is to investigate the role of social media in communication discourse in the Islamic Middle East and North African (MENA) countries. Design/methodology/approach – By applying the theory of social networks and a method known as critical discourse analysis (CDA) this study investigates the role of social media in the recent waves of popular unrest in the MENA r...

OBJECTIVES The Middle East and North Africa (MENA) region is perceived to have limited HIV data. The objective of this study was to quantitatively characterise the progress in HIV research in this region since the discovery of the epidemic. METHODS Four indices were defined and implemented to measure the progress of HIV research using the PubMed, Embase, MENA HIV/AIDS Epidemiology Synthesis P...

This paper starts from the premise that private sector development is of crucial importance to the future development of MENA countries. It demonstrates the relative importance of various institutional constraints, in general, and impediments to dispute resolution, in particular, in reducing the competitiveness of private firms in the MENA region through by increasing transaction costs. It desc...

The mere association of the words sexually transmitted infections (STIs), including HIV/AIDS, and sexuality, to Middle East and North Africa (MENA) in any discussion, social or academic, seems to elicit heated debates and controversy. The MENA region is, in the minds of many, an area where socio-cultural sensitivities surrounding sex and disease still abound. Are there HIV epidemics shrouded be...

Mena [mammalian Ena (Enabled)]/VASP (vasodilator-stimulated phosphoprotein) proteins are the homologues of Drosophila Ena. In Drosophila, Ena is a substrate of the tyrosine kinase DAbl (Drosophila Abl). However, the link between Abl and the Mena/VASP family is not fully understood in mammals. We previously reported that Abi-1 (Abl interactor 1) promotes phosphorylation of Mena and BCAP (B-cell ...

The cytosolic domain of the beta-amyloid precursor protein APP interacts with three PTB (phosphotyrosine binding domain)-containing adaptor proteins, Fe65, X11, and mDab1. Through these adaptors, other molecules can be recruited at the cytodomain of APP; one of them is Mena, that binds to the WW domain (a protein module with two conserved tryptophans) of Fe65. The enabled and disabled genes of ...

BACKGROUND The epidemiology of Chikungunya virus (CHIKV) in the Middle East and North Africa (MENA) is not well characterized despite increasing recognition of its expanding infection and disease burden in recent years. METHODOLOGY / PRINCIPAL FINDINGS Following Cochrane Collaboration guidelines and reporting our findings following PRISMA guidelines, we systematically reviewed records describ...

BACKGROUND The Rho GTPases Rho, Rac, and Cdc42 regulate the organization of the actin cytoskeleton by interacting with multiple, distinct downstream effector proteins. Cdc42 controls the formation of actin bundle-containing filopodia at the cellular periphery. The molecular mechanism for this remains as yet unclear. RESULTS We report here that Cdc42 interacts with IRSp53/BAP2 alpha, an SH3 do...