Wnt/β-catenin signalling pathway plays important roles in embryonic development and carcinogenesis. Overactivation of the pathway is one of the most common driving forces in major cancers such as colorectal and breast cancers. The downstream effectors of the pathway and its regulation of carcinogenesis and metastasis are still not very well understood. In this study, which was based on two geno...

T he main objective of this study is to estimate the spatial spillover effects of the economic growth among the selected countries of MENA region. For this purpose, the Spatial Durbin Model in the framework of spatial dynamic panel data was estimated during the period of 1970-2010. The spatial Diagnostic tests affirmed the occurrence of spatial positive autocorrelation phenomenon for...

he year 2011 was one of remarkable and uneven transition in the Middle East and North Africa (MENA) region. Mass uprisings in cities in Tunisia, Egypt and Libya brought about changes in governments; protests have quelled in Bahrain, Syria and Yemen; and cautious reforms were introduced in Saudi Arabia. The situation remains very fluid, but there is a consensus that 2011 ushered in a period of f...

The actin regulatory proteins Ena/VASP (Enabled/Vasodilator stimulated phosphoprotein) family is involved in the control of cell motility and adhesion. They are important in the actin-dependent processes where dynamic actin reorganization it is necessary. The deregulation of actin cycle could have an important role in the cells' malignant transformation, tumor invasion or metastasis. Recently s...

During breast cancer progression, alternative mRNA splicing produces functionally distinct isoforms of Mena, an actin regulator with roles in cell migration and metastasis. Aggressive tumor cell subpopulations express Mena(INV), which promotes tumor cell invasion by potentiating EGF responses. However, the mechanism by which this occurs is unknown. Here we report that Mena associates constituti...

OBJECTIVE The optimal long-term vaccination strategies to provide population-level protection against serogroup A Neisseria meningitidis (MenA) are unknown. We developed an age-structured mathematical model of MenA transmission, colonization, and disease in the African meningitis belt, and used this model to explore the impact of various vaccination strategies. METHODS The model stratifies th...

Mena, a member of the Ena/VASP family of actin regulatory proteins, modulates microfilaments and interacts with cytoskeletal proteins associated with heart failure. Mena is localized at the intercalated disc (ICD) of adult cardiac myocytes, colocalizing with numerous cytoskeletal proteins. Mena's role in the maintainence of mechanical myocardial stability at the cardiomyocyte ICD remains unknow...