Metastatic carcinoma of the nervous system limited to the meninges IS rare, but it has been frequently described. Carcinomatosis of this sort is usually confined to the meninges over the cerebral hemispheres and only occasionally spreads to the spinal membranes. Meningeal carcinomatosis confined to the spinal cord and to a portion of the base of the brain without involvement of the cerebrum its...

Development of ceftriaxone loaded nanostructured lipid carriers to increase permeability across uninflamed meninges after parenteral administration. Lipids were selected by theoretical and experimental techniques optimization NLCs done response surface methodology using Box-Behnken design. The Δδt for glyceryl monostearate Capryol90 4.39 2.92 respectively. drug had maximum solubility 0.175% (w/...

AIM The spinal cord is drained by three interconnected venous systems. Among them the extrinsic system of dorsal thoracolumbar region with its radicular communications liable to get injured due anatomical position. With increasing case reports post puncture hematomas, revisiting intrathecal has become a necessity. MATERIAL AND METHODS In tertiary teaching institution, 25 adult cadavers were dis...