In a population of approximately 100,000, 99% of the population was treated with at least one dose of sulphadimidine snuff and 94% with three or four doses over a period of two days. A dramatic reduction in the incidence of cerebrospinal meningitis followed immediately thereafter in the treated population, while the incidence continued to rise in adjacent comparable districts which had not been...

A meningococcal serogroup A polysaccharide/tetanus toxoid conjugate vaccine (PsA-TT) (MenAfriVac(™) ) is being deployed in countries of the African meningitis belt. Experience with other polysaccharide/protein conjugate vaccines has shown that an important part of their success has been their ability to prevent the acquisition of pharyngeal carriage and hence to stop transmission and induce her...

History, epidemiology, pathogenesis, clinical manifestations, diagnosis, antimicrobial susceptibility and prevention. Indian J Med Microbiol. 2006;24:7-19. 2. Sinclair D, Preziosi MP, John TJ, Greenwood B. The epidemiology of meningococcal disease in India. Trop Med Int Health. 2010;15:1421–35. 3. Khatami A, Pollard AJ. The epidemiology of meningococcal disease and the impact of vaccines. Exper...

Endemic and epidemic meningococcal disease constitutes a major public-health problem in African countries of the 'meningitis belt' where incidence rates of the disease are many-fold higher (up to 25 cases per 100,000 population) than those in industrialized countries, and epidemics of meningococcal disease occur with rates as high as 1,000 cases per 100,000 people. Using the precedent establish...

Herpes simplex virus 2 (HSV-2) is a well-known cause of neurological complications. This case study describes the first reported reactivated HSV-2 myelitis, which was induced by immunosuppression due to sepsis. During treatment meningococcal meningitis, patient developed quadriparesis and later diagnosed as mimicking ICU-acquired weakness. The emphasizes importance excluding viral myelitis befo...