Nalbuphine hydrochloride is a relatively new agonist-antagonist drug structurally related to the potent narcotic, oxymorphone (Numorphan®), and the potent narcotic antagonist, naloxone (Narcan®). (Figure 1.) Nalbuphine has a potency equivalent to morphine sulphate and meperidine (10 mg morphine sulphate and 75 mg meperidine being equivalent to 20 mg nalbuphine), 1 with an abuse potential which ...

BACKGROUND Different levels of pharmacological sedation ranging from minimal to general anesthesia are often used to increase patient tolerance for a successful colonoscopy. However, sedation increases the risk of respiratory depression and cardiovascular complications during colonoscopy. OBJECTIVES We aimed to compare the propofol and midazolam/meperidine sedation methods for colonoscopy pro...

When meperidine (Demerol) was shown to possess marked analgesic properties (Eisleb and Schaumann, 1939) and thus became the first potent synthetic analgesic drug, the importance of the 1,4-substituted piperidine nucleus in providing analgesic activity became apparent. Many modifications of this basic chemical structure have been synthesized and studied pharmacologically in an attempt to achieve...

S. HERLING, R.J. VALENTINO, R.E. SOLOMON and J.H. WOODS, Narcotic discrimination in pigeons." Antagonism by naltrexone, European J. Pharmacol. 105 (1984) 137-142. In pigeons trained to discriminate between morphine (10 mg/kg) and saline, both morphine and ethylketazocine produced dose-related morphine-appropriate responding. The maximum effect produced by meperidine, however, was only 60% of th...

Intrathecal meperidine administration can provide surgical anaesthesia and postoperative analgesia for about two to six hours. We have observed two cases of respiratory depression associated with meperidine spinal anaesthesia. An 81-yr-old woman received 50 mg intrathecal meperidine for inguinal hernia repair. Supplemental oxygen was administered at 3 L.min-1 by nasal prongs. About 40 min later...

This study compared the sedative effectiveness of orally administered ketamine to a combination of oral meperidine/promethazine (Demerol/Phenergan) in two groups of children. One group received ketamine at a dose of 6 mg/kg and the other group received meperidine/promethazine combination at a dose of 2 mg/kg and 0.5 mg/kg, respectively. All children received nitrous oxide 30-50% titrated to eff...

BACKGROUND Pain following laparoscopy could be due to different causes requiring effective postoperative analgesia. OBJECTIVES In the present study, we evaluated the combined effect of intraperitoneal infiltration of bupivacaine-meperidine versus intravenous infusion of paracetamol on pain relief after diagnostic gynecologic laparoscopy. PATIENTS AND METHODS In this prospective study, 90 fe...

Introduction: The aim of this study was to investigate low-dose intrathecal meperidine for prevention or alleviation of shivering after induction of spinal anesthesia for transurethral resection of the prostate (TURP). Materials and Methods: In a randomized controlled trial, 80 patients scheduled for TURP under spinal anesthesia were assigned into two groups of case and control. Spinal anesthes...