نتایج جستجو برای: mepscs

تعداد نتایج: 333  

Journal: :Journal of neurophysiology 1997
N E Schoppa G L Westbrook

Olfactory bulb mitral cells express group I (mGluR1), group II (mGluR2), and group III (mGluR7 and mGluR8) metabotropic glutamate receptors. We examined the role of these mGluRs on excitatory synaptic transmission in cultured mitral cells with the use of whole cell patch-clamp recordings. The effects of group-selective mGluR agonists and antagonists were tested on alpha-amino-3-hydroxy-5-methyl...

Journal: :British journal of pharmacology 2011
Huizhi Du Xiaolei Chen Jian Zhang Chu Chen

BACKGROUND AND PURPOSE Endocannabinoids have both anti-inflammatory and neuroprotective properties against harmful stimuli. We previously demonstrated that the endocannabinoid 2-arachidonoylglycerol (2-AG) protects hippocampal neurons by limiting the inflammatory response via a CB(1) receptor-dependent MAPK/NF-κB signalling pathway. The purpose of the present study was to determine whether PPAR...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Annie K Ting Yongjun Chen Lei Wen Dong-Min Yin Chengyong Shen Yanmei Tao Xihui Liu Wen-Cheng Xiong Lin Mei

Neuregulin 1 (NRG1) and its receptor ErbB4 are both susceptibility genes of schizophrenia. However, little is known about the underlying mechanisms of their malfunction. Although ErbB4 is enriched in GABAergic interneurons, the role of NRG1 in excitatory synapse formation in these neurons remains poorly understood. We showed that NRG1 increased both the number and size of PSD-95 puncta and the ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Katie M Wiens Hang Lin Dezhi Liao

Glutamatergic synapses switch from nonspiny synapses to become dendritic spines during early neuronal development. Here, we report that the lack of sufficient Rac1, a small RhoGTPase, contributes to the absence of spinogenesis in immature neurons. The overexpression of green fluorescence protein-tagged wild-type Rac1 initiated the formation of dendritic spines in cultured dissociated hippocampa...

Journal: :Journal of pharmacological sciences 2011
Yoshiaki Ohi Saori Tsunekawa Akira Haji

Dextromethorphan (DEX) is a widely used non-opioid antitussive. However, the precise site of action and its mechanism were not fully understood. We examined the effects of DEX on AMPA receptor-mediated glutamatergic transmission in the nucleus tractus solitarius (NTS) of guinea pigs. Excitatory postsynaptic currents (evoked EPSCs: eEPSCs) were evoked in the second-order neurons by electrical st...

Journal: :Molecular Pain 2009
Hiroki Toyoda Ming-Gao Zhao Min Zhuo

The anterior cingulate cortex (ACC) is a forebrain structure that plays important roles in emotion, learning, memory and persistent pain. Our previous studies have demonstrated that the enhancement of excitatory synaptic transmission was induced by peripheral inflammation and nerve injury in ACC synapses. However, little information is available on their presynaptic mechanisms, since the source...

Journal: :Journal of neuropathology and experimental neurology 2011
Sabine Koch Svetlana M Molchanova Ann K Wright Andrew Edwards Jonathan D Cooper Tomi Taira Thomas H Gillingwater Jaana Tyynelä

Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of CTSD deficiencies. To identify the early events that lead to synaptic alterations, we investigated synaptic ultrastructure and function in pre...

Journal: :Molecular Pain 2005
Meng Chen Jianguo G Gu

Of the six lamina regions in the dorsal horn of the spinal cord, lamina I is a major sensory region involved in nociceptive transmission under both physiological and pathological conditions. While P2X receptors have been shown to be involved in nociception, it remains unknown if P2X receptors are involved in nociceptive transmission to lamina I neurons. Using rat spinal cord slice preparations ...

2016
Dong-Dong Liu Jun-Mei Lu Qian-Ru Zhao Changlong Hu Yan-Ai Mei

Growth differentiation factor-15 (GDF-15) has been implicated in ischemic brain injury and synapse development, but its involvement in modulating neuronal excitability and synaptic transmission remain poorly understood. In this study, we investigated the effects of GDF-15 on non-evoked miniature excitatory post-synaptic currents (mEPSCs) and neurotransmitter release in the medial prefrontal cor...

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