S INCE THE INTRODUCTION of the folic acid antagonists into clinical medicine’ several other agents with an effect on acute leukemia have been employed: purine analogs,2 corticotropin and corticosteroids.3 Despite the number of compounds available, all patients do not derive benefit from them; when improvement does occur it is usually short lasting. Until other more effective antileukemic treatm...

systemic amyloidosis is a very rare complication of inflammatory bowel disease (ibd). the reported cases of secondary amyloidosis in children with ibd are much fewer than those reported in adults. herein, a teenage boy with crohn’s disease is presented who developed nephrotic syndrome due to renal involvement secondary to amyloidosis, whereas the patient was under treatment with corticosteroid ...

Several 9-alkyl, 6-thiopurines have been reported to have more favorable therapeutic indexes than do the parent drugs, 6mercaptopurine (MP) and 6-thioguanine (TG). Some of these compounds were reported to be active against cells in culture resistant to 6-thiopurines, and it has been assumed that their mechanisms of action may differ from those of TG and MP. 9(n-Butyl)-6-thioguanine was essentia...

DBA/3 mice and BALB/c X DBA/2 F1 mice were inoculated i.p. with 1 X 10(5) L1210 leukemia cells on Day 0. Beginning with Day 1 following inoculation, the animals were given injections of 6-mercaptopurine riboside (200 mg/kg i.p.) once daily for 5 consecutive days in combination with a single s.c. injection of levamisole (LMS) (10 mg/kg). In DBA/2 mice, a marked decrease in the total peritoneal c...

Mercaptopurine is a purine antagonist, belonging to the class of antimetabolites. Its oral absorption is erratic and variable throughout GIT, with bioavailability of 5-37% and belongs to Biopharmaceutical Classification System (BCS) class IV. The focus of the present study was to improve solubility of mercaptopurine and to release the drug uniformly throughout the GIT by formulating into a nove...

azathiprine or 6-mercaptopurine: evidence for a potentially serious drug interaction [Letter]. Gastroenterology 1999;116:1505–6. 5. Szumlanski CL, Weinshilboum RM. Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine. Br J Clin Pharmacol 1995;39:456–9. 6. Lowry PW, Franklin CL, Weaver AL, Szumlanski CL, Mays DC, Lof...