OBJECTIVE To evaluate the current spectrum of hepatobiliary disorders in children in Northern India. SETTING Tertiary level referral hospital. METHODS All children with hepatobiliary disorders presenting between January 1992 through July 1995 were evaluated by clinical assessment, liver function tests, viral and autoimmune markers, liver biopsy, copper studies and other relevant investigati...

Inherited liver diseases are a group of metabolic and genetic defects that typically cause early chronic liver involvement. Most are due to a defect of an enzyme/transport protein that alters a metabolic pathway and exerts a pathogenic role mainly in the liver. The prevalence is variable, but most are rare pathologies. We review the pathophysiology of such diseases and the diagnostic contributi...

clinical differential diagnosisthe organic acidemias are important in the differential diagnosis of metabolic and neurologic derangement in the neonate and of new-onset neurologic signs in the older child. a-organic aciduriaseveral disorders, not classified as primary disorders of organic acid metabolism, have a characteristic urinary organic acid profile that suggests the appropriate diagnosis...

Emerging evidence strongly supports that changes in the HDL metabolic pathway, which result in changes in HDL proteome and function, appear to have a causative impact on a number of metabolic disorders. Here, we provide a critical review of the most recent and novel findings correlating HDL properties and functionality with various pathophysiological processes and disease states, such as obesit...

The purpose of the Liver Expert Panel was to provide advice to the National Lipid Association's (NLA) Safety Task Force in response to specific questions concerning liver-associated risks of statin therapy. The panel was composed of academic hepatologists with clinical and research interests in nonalcoholic fatty liver disease, lipid metabolic disorders, and drug hepatotoxicity.

common cancer and the third leading cause of cancer-related deaths. A known risk factor for HCC is non-alcoholic fatty liver disease (NAFLD), a continuum hepatic disorders related to obesity metabolic syndrome. AIM: We conducted an observational study identify factors hepatocellular in patients with who came SMHRC Nagpur routine visit. MATERIAL AND METHODS: The included 300 people aged 35 85 ye...

nonalcoholic fatty liver disease (nafld) is one of the aspects of metabolic syndrome (mets). due to the increase of mets in iran, this study was conducted to determine the prevalence of nafld, its potential predictors and their sex distribution in north of iran, amol.in 2008 this population based cross-sectional study included 5023 adult individuals who were randomly selected from amol healthca...

Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent disorder in which fat accumulates excessively in the liver. The disease affects between 10% to 30% of the general population and up to 90% in obese patients [1]. Fatty liver, the first step of NAFLD, is linked with insulin resistance, a well-known condition that predisposes to the development of metabolic disorders such as diabetes ...