Trypanosoma cruzi metacyclic trypomastigotes invade and replicate in the gastric mucosal epithelium after oral infection. In this study we analyzed the process of infection by T. cruzi isolates deficient in the expression of gp82, the metacyclic stage-specific surface glycoprotein implicated in target cell entry in vitro and in promoting mucosal infection in mice after oral challenge. Mice infe...

We compute the stable reduction of some Galois covers of the projective line branched at three points. These covers are constructed using Hurwitz spaces parameterizing metacyclic covers. The reduction is determined by a certain hypergeometric differential equation. This generalizes the result of Deligne and Rapoport on the reduction of the modular curve X (p).

Virulence for BALB/c mice, infectivity for Phlebotomus papatasi, haemagglutination activity and expression of metacyclic lipophosphoglycan (LPG) were studied in four strains of Leishmania major (LV561, FV1, L119 and Neal) and various lines of the LV561 strain. Attenuated line LV561/AV was passaged five times through sandflies or mice and the resulting lines (AVS5 and AVM5, respectively) and two...

Abstract In this paper, we set ? ? ( G stretchy="false">) \eta(G) to be the number of conjugacy classes maximal cyclic subgroups a finite group ????. We compute for all metacyclic ????-groups. show that if ???? is ????-group order <m:msup...

Four different trypanosome isolates from human patients isolated in 1979 during the epidemic of sleeping sickness in Busoga, south-east Uganda, were characterized by the following methods: isoenzyme analyses of bloodstream forms by isoelectric focusing; in vitro tests of human serum resistance of bloodstream as well as metacyclic forms; tsetse fly transmission through Glossina morsitans central...

Curran, S.J., Hamilton paths in Cayley digraphs of metacyclic groups, Discrete Mathematics 115 (1993) 133-139. We obtain a characterization of all Hamilton paths in the Cayley digraph of a metacyclic group G with generating set {x, y} where (yx-‘) a G. The abundance of these Hamilton paths allows us to show that Hamilton paths occur in groups of at least two.

In the mammalian bloodstream, African trypanosomes express the variant surface glycoprotein (VSG), continual switching of which allows evasion of the host immune response. Bloodstream VSG genes are transcribed from polycistronic bloodstream expression sites with promoters which are located 45-60 kb upstream. These promoters are not exclusively stage-regulated, being active in the insect midgut ...

The transformation of epimastigotes into metacyclic trypomastigotes involves changes in the pattern of expressed genes, resulting in important morphological and functional differences between these developmental forms of Trypanosoma cruzi. In order to identify and characterize genes involved in triggering the metacyclogenesis process and in conferring to metacyclic trypomastigotes their stage s...

In this paper we find the complete structure for the automorphism groups of metacyclic minimal nonabelian 2-groups. This, together with [6, 7], gives the complete answer to the Question 15 from [5] (respectively Question 20 from [4]) in the case of metacyclic groups. We also correct some inaccuracies and extend the results from [13].

BACKGROUND To invade target cells, Trypanosoma cruzi metacyclic forms engage distinct sets of surface and secreted molecules that interact with host components. Serine-, alanine-, and proline-rich proteins (SAP) comprise a multigene family constituted of molecules with a high serine, alanine and proline residue content. SAP proteins have a central domain (SAP-CD) responsible for interaction wit...