Besides cytotoxic DNA damage irradiation of tumor cells triggers multiple intra- and intercellular signaling processes, that are part a multilayered, treatment-induced stress response at the unicellular pathophysiological level. These processes intertwined with intrinsic acquired resistance mechanisms to toxic effects ionizing radiation thereby co-determine radiotherapy. Proteolysis structural ...

ADAM (a disintegrin and metalloproteinase) 10 is a key member of the ADAM family of disintegrin and metalloproteinases which process membrane-associated proteins to soluble forms in a process known as 'shedding'. Among the major targets of ADAM10 are Notch, EphrinA2 and CD44. In many cell-based studies of shedding, the activity of ADAM10 appears to overlap with that of ADAM17, which has a simil...

resin- dentin interface hydrolysis is one of the greatest problems in restorative dentistry, because of collagenolytic and proteolytic activity of dentin enzymes. the aim of this study was to compare the effect of chx 2% and naocl 5% as rewetting agent on resin-dentin micro tensile bond strength.methods: 45 extracted, human caries-free third molar teeth were collected. after exposing of superfi...

matrix metalloproteinases (mmps) play an important role in gastric cancer (gc). accumulated evidence suggests that functional mmp-1 and mmp-7 gene polymorphisms are associated with several tumors. the aim of this study was to investigate two single nucleotide polymorphisms, mmp-1 -1607 1g/2g and mmp-7 -181 a/g, and their potential relationship with gc. we examined 246 gc  patients and 252 age-a...

objective: diabetes plays an important role in the progression of tissue damage. influencing factors of the cellular matrix can lead to changes in the structure and function of tissues or their failure. herbal consumption can be effective in reducing tissue failure. the aim of the this study is to research the effect portulaca oleracea seeds on the levels of matrix metalloproteinase 2, 9 and ti...

The aim of this study was to assess the expression of several metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in exudative pleural effusions, and their relationship with inflammatory and fibrinolytic mediators in parapneumonic effusions. The study included 51 parapneumonic effusions (30 empyema or complicated parapneumonic, 21 noncomplicated parapneumonic), 28 tube...