In this work behavior of active pharmaceutical substances  methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form – freeze dried powder for injections was examined. The goal was to evaluate the chemical stabilities of methylprednisolone sodium succinate packaged in dual chamber vial, as a specific container closure system. The effect of dif...

1. As it has been suggested that the beneficial effect of methylprednisolone in shock is due to its effect on erythraocyte oxygen affinity, we studied its effect on incubated erythrocytes and on haemoglobin solution. 2. Incubation of fresh whole blood anticoagulated with acid/citrate/dextrose with methylprednisolone (7 mmol/l) produced a significant decrease in oxygen affinity, which was not se...

INTRODUCTION In spite of the wide usage of corticosteroids for the treatment of a plethora of diseases, sometimes they can induce immediate hypersensitivity reactions, which are however uncommon. CASE OUTLINE We report a case of immediate allergic reaction induced by intravenous methylprednisolone given before operation for surgical repair of an arm contracture as a sequel of burns, which the...

A recent paper described a randomised comparative study of intravenous (IV) pulse methylprednisolone versus infliximab treatment in patients for whom methotrexate treatment had failed. The conclusions that infliximab treatment offered substantial benefits over IV methylprednisolone may be correct, but the design of the trial has resulted in a biased assessment in favour of IV infliximab treatme...

Purpose: Through observing the effect of high-dose methylprednisolone treatment on active AS with acute anterior uveitis (AAU) to evaluate the influence of methylprednisolone on the serological cytokines IL-23 and IL-17 in AS patients with AAU. We try to explore the clinical effect and possible mechanism of high-dose methylprednisolone treatment on AS with AAU. Methods: The present study includ...

STUDY DESIGN A retrospective study. PURPOSE The aim of this study was to evaluate the effects of delayed hypothermia on spinal cord injuries in rats. In addition, the effect of methylprednisolone on therapeutic window of hypothermia was evaluated. OVERVIEW OF LITERATURE Several studies have demonstrated that early hypothermia is the most effective neuroprotective modality. However, delayed ...

The extent to which treatment with low doses of the nonfluorinated steroid methylprednisolone affects diaphragm contractility and morphology is unknown. In the present study, we compared the effects of equipotent doses of methylprednisolone and deflazacort, an oxazoline derivate of prednisolone with less systemic side-effects on bone structure and carbohydrate metabolism. Twenty six male adult ...