نتایج جستجو برای: methylpyrrole
تعداد نتایج: 138 فیلتر نتایج به سال:
Fluorophores that are conjugated with N-methylpyrrole-N-methylimidazole (Py-Im) polyamides postulates versatile applications in biological and physicochemical studies. Here, we show the design and synthesis of new types of pyrene-conjugated hairpin Py-Im polyamides (1-5). We evaluated the steady state fluorescence of the synthesized conjugates (1-5) in the presence and absence of oligodeoxynucl...
Synthesis of directly linked diazine isosteres of pyrrole-polyamide that photochemically cleave DNA.
A distamycin model containing an isosteric diazine linked pyrrole has been designed and synthesized. The key steps of the synthesis involved the successful diazotization of the 4-amino-pyrrole derivatives to give the diazomium salts, which undergo coupling reactions with N-methylpyrrole to yield the directly linked diazine compounds. The amide isosteric-diazine pyrrole I demonstrated photo-indu...
In this paper, potentiostatic and galvanostatic deposition (electrochemical deposition) processes have been used for the obtained of a new composite polymer: N-methylpyrrole-sodium 1-dodecanesulfonate/poly 2-methylthiophene (PNMPY-1SSD/P2MT) coatings over brass electrode corrosion protection. The sodium 1-dodecanesulfonate as dopant ion employed in electropolymerization procedure can meaningful...
A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and efficient method. The final compounds obtained were screened for their inhibitory potency against monoamine oxidase (MAO) A and B. The newly synthesized compounds 2a-2n specifically inhibited monoamine oxidases, displaying notably low IC50 values. Compounds 2i and 2j, with a CF₃ and OH group on the 4-position ...
Targeting the genome with sequence-specific DNA-binding molecules is a major goal at the interface of chemistry, biology, and precision medicine. Polyamides, composed of N-methylpyrrole and N-methylimidazole monomers, are a class of synthetic molecules that can be rationally designed to "read" specific DNA sequences. However, the impact of different chromatin states on polyamide binding in live...
The specificity of the reaction for amino sugars discovered by Elson & Morgan (1933) has been increased by several workers through knowledge of some of the intermediates involved. The interference by amino acids and glucose was overcome in different ways (Schloss, 1951; Immers & Vasseur, 1952; Cessi, 1952; Cessi & Piliego, 1960). The separation of a volatile fraction among the products of conde...
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