Introduction Frontal bone of the skull develops in two halves during the fetal life separated by the metopic suture. The suture normally disappears soon after the birth [1]. The persistent complete metopic suture extending from the nasion to bregma is called metopism [2]. Lambda represent the meeting point of the sagittal and lambdoid suture. It represents the site of posterior median fontanel ...

Craniosynostosis is a disease defined by premature fusion of one or more cranial sutures. The mechanistic pathology of single-suture craniosynostosis is complex and while a number of genetic biomarkers and environmental predispositions have been identified, in many cases the causes remain controversial and inconclusive. In this study, gene expression data from 199 patients with isolated sagitta...

PURPOSE: Nonsyndromic craniosynostosis (NSC) has been associated with a greater risk of neurocognitive aberrations such as learning disorders, memory and attention deficits, and visuospatial abilities. Previously, our group has performed resting-state functional MRI (fMRI) studies in patients with sagittal NSC (SSO), and has found altered functional connectivity that may underlie some of the ne...

Baraitser-Winter cerebrofrontofacial syndrome (BWCFF) (BRWS; MIM #243310, 614583) is a rare developmental disorder affecting multiple organ systems. It is characterised by intellectual disability (mild to severe) and distinctive facial appearance (metopic ridging/trigonocephaly, bilateral ptosis, hypertelorism). The additional presence of cortical malformations (pachygyria/lissencephaly) and oc...

The present study describes the presence of os inca, incomplete metopic suture with asymmetrical frontal sinuses and multiple sutural deformities in a skull bone. Os inca has been reported to be associated with other cranial deformities. However, the present study, besides reporting os inca and associated sutural abnormalities, also highlights the presence of an unusual pterion in such cases. T...

INTRODUCTION Opitz trigonocephaly C syndrome (OTCS) is a rare malformation syndrome with the following features: synostosis of metopic suture, craniofacial abnormalities, severe mental retardation and a multitude of pathological findings affecting almost every organ system. OTCS is associated with a high mortality rate. CASE PRESENTATION We describe the case of a Caucasian male baby who died ...