Since 2003 when the international norm for implementation of quality management in medical laboratories (EN ISO 15189, Medical laboratories--Particular requirements for quality and competence) was established and accepted, accreditation has become practical, generally accepted method of quality management and confirmation of technical competence of medical laboratories in the whole world. This ...

To be accurate and equivalent, laboratory results should be traceable to higher-order references. Furthermore, their quality should fulfill acceptable measurement uncertainty as defined to fit the intended clinical use. With this aim, in vitro diagnostics (IVD) manufacturers should define a calibration hierarchy to assign traceable values to their system calibrators and to fulfill during this p...

The standardization of measurements is of high priority in Laboratory Medicine, its purpose being to achieve closer comparability of results obtained using routine analytical systems. In order to achieve standardization, an approach is required that provides reliable transfer of the measurement values from the highest hierarchical level to methods which are routinely used in the clinical labora...

A temperature controlled 1 Ω–10 kΩ Standard resistors setup was developed at National Institute of Metrological Research, (INRIM). The aim of this realization was the involvement of the setup resistors in the traceability transfer process to high accuracy multifunction electrical instruments used in Secondary Electrical Calibration Laboratories or even their use as primary Standards in high lev...

1. Algeciras-Schimnich A, Bruns DE, Boyd JC, Bryant SC, LaFortune KA, Grebe SKG. Failure of current laboratory protocols to detect lot-to-lot reagent differences: findings and possible solutions. Clin Chem 2013;59:1187–94. 2. Bais R. What information should manufacturers provide on their procedures? Clin Chem 2006; 52:1624–5. 3. Bais R, Armbruster D, Jansen RTP, Klee G, Panteghini M, Passarelli...

BACKGROUND Accurate measurement of serum cortisol is required to diagnose and treat adrenal disorders. Although certified reference materials (CRMs) are available to standardize cortisol measurements, External Quality Assessment (EQA) schemes still demonstrate a wide dispersion of results. We present a serum cortisol candidate reference measurement procedure that, through analysis of a Joint Co...

The analysis of the concept Open-Science Space is carried out. existence ways to achieve reproducibility and traceability research results performed by a group worldwide situated Cyber-physical system operators/supervisors shown. Ways ensure efficient operation systems as complex technological nondemountable objects with high requirements for metrological characteristics have been studied. To d...

We present an isothermal chamber designed and realized at the Italian Metrological Institute (INRiM) to stabilize temperature of a quartz cell for Doppler-broadened precision spectroscopy mercury atoms in UV region practical realization new definition kelvin. The challenge this apparatus is capability control, with great accuracy, non-cylindrical cavity containing vapors. was actively controlle...

The eye-tonometers are the important medical devices with measuring function which necessary for screenings of intraocular hypertension (a serious risk factor glaucoma). However, it is not an easy task to ensure their correct metrological traceability. There needed only a wide range various equipment but also relevant know-how. Hence, training centre this quantity was established at Czech Metro...