objective(s): anti-epileptic drugs (aeds) have the potential to affect fetal development throughout pregnancy. considering the broad therapeutic indications of pregabalin (pgb), its potential teratogenic effects and the levels of homocysteine have been studied.   materials and methods: timed-pregnant mice received one of three doses of pgb (20, 40 or 80 mg/kg/day) or the vehicle control during ...

The effects of zidovudine (AZT) on the fetus were investigated in pregnant mice by using parameters such as the number of fetuses, fetal size, and the fetal hepatic cell clonogenic assay. AZT caused dose-dependent toxicity to the fetus upon administration via drinking water to pregnant mice from days 1 to 13 of gestation. At the 0.5-mg/ml dose level, AZT caused a decrease in the number of fetus...

The Ah locus in the mouse controls the induction of cytochrome P1-450 and at least eleven associated monooxygenase activities. These enzyme systems metabolically potentiate and detoxify drugs, environmental pollutants, and other foreign chemicals, as well as numerous endogenous substrates. For certain substrates, it is known that cytochrome P1-450 produces different reactive intermediates and p...

  Objective(s): Anti-epileptic drugs (AEDs) have the potential to affect fetal development throughout pregnancy. Considering the broad therapeutic indications of pregabalin (PGB), its potential teratogenic effects and the levels of homocysteine have been studied.   Materials and Methods: Timed-pregnant mice received one of three doses of PGB (20, 40 or 80 mg/kg/day) or the vehicl...

Many factors affect the rate of fetal growth and development in addition to overall fetal well-being. In eutherian mammals, the placenta serves as the primary mediator and modulator of those factors that ultimately determine development rate. The placenta accomplishes this task in the following ways: (a) by serving as the site of nutrient and waste transfer between the mother and fetus; (b) by ...