The finite-wavelength instability gives rise to a new type of wave in reaction-diffusion systems: packet waves, which propagate only within a wave packet, are found in experiments on the Belousov-Zhabotinsky reaction dispersed in water-in-oil AOT microemulsion (BZ-AOT) as well as in model simulations. Inwardly moving packet waves with negative curvature occur in experiments and in a model of th...

The purpose of this study was to develop a docetaxel microemulsion containing an anti-tumor synergistic ingredient (Brucea javanica oil) and to investigate the characteristics of the microemulsion. Brucea javanica oil contains oleic acid and linoleic acids that have been shown by animal and human studies to inhibit tumor formation. The microemulsion containing Brucea javanica oil, medium-chain ...

The objective of the present study was to design and develop a microemulsion based transungual drug delivery formulation of ciclopirox olamine using colloidal carrier for treatment of onychomycosis. Capmul PG8 was selected as oil phase due to the high solubility of ciclopirox in it as compared to other oils and Cremophor EL and Transcutol P were used as surfactant and cosurfactant respectively....

BACKGROUND Microemulsion propofol produces more frequent and severe pain upon injection than lipid emulsion propofol. This study examined the analgesic effect of lidocaine-premixed microemulsion propofol in patients pretreated with remifentanil. The induction of anesthesia with this combination was compared with microemulsion propofol accompanied with either remifentanil or lidocaine. METHODS...

BACKGROUND Aquafol, a microemulsion propofol, causes more severe and frequent pain on injection than propofol. The purpose of this study was to compare a combination of lidocaine and ketamine on aquafol-induced pain with lidocaine or ketamine alone during the induction of anesthesia. METHODS In this prospective, randomized, double-blinded study, 130 healthy patients who were undergoing electi...

In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...

To improve the efficiency of the intradermal delivery of genistein and other two isoflavones (daidzein and biochanin A), we tried to clarify the usefulness of microemulsion by in vitro study on excised guinea pig dorsal skin and Yucatan micropig skin. Using microemulsion consisting of isopropyl myristate (IPM), 150 mM NaCl solution, Tween 80 and ethanol as a vehicle, the solubility of all the i...

The purpose of present study was to formulate microemulsion composed of oleic acid+phosphate buffer (PB)+Tween 80+ethanol and to investigate its potential as drug delivery system for an antitubercular drug rifampicin. The pseudo-ternary phase diagram has been delineated at constant surfactant/cosurfactant ratio (K(m) 0.55). Conductivity (sigma) and viscosity (keta) studies with variation in Phi...

The bioavailability of two microemulsion formulations of cyclosporine (Drug A, cyclosporine Neoral, Sandoz Pharma Ltd., Switzerland and Drug B, cyclosporine Bioral, Panacea Biotec Ltd., India) was compared in 12 healthy volunteers in a randomized, double blind, cross over manner. Blood cyclosporine levels were analyzed by high performance liquid chromatography. The peak concentration was 1600.6...

objective(s):the objective of this study was to find a stable microemulsion vehicle for transdermal delivery of ibuprofen to improve the skin permeability. materials and methods: microemulsion was prepared using different sorts of oils, surfactants and co-surfactants. pseudo-ternary phase diagrams were used to evaluate the microemulsion domain. the effects of oleic acid and surfactant mixture o...