Airway inflammation is considered to be the primary component contributing to the heterogeneity and severity of airway disorders. Therapeutic efficacies of diverse novel biologics targeting the inflammatory pathways are under investigation. One such target is IL-5, a type-1 cytokine that is central to the initiation and sustenance of eosinophilic airway inflammation. Over the past decade, anti-...

surfactant molecules are used as interesting tools to study the structure, function and stability of proteins. protonation states of amino acids may be changed in the presence of surfactants. in this work, using experimental observations and molecular dynamic simulation, the effects of sodium dodecyl sulfate on the acid dissociation constants of tryptophan was examined. the acid–base equilibriu...

Background This study aimed to describe the epidemiologic characteristics of

Background Thrombotic thrombocytopenic purpura (TTP) and Microscopic polyangiitis (MPA) rarely occur in conjunction. Autoimmune TTP is caused by autoantibodies to the ADAMTS13 protein that cleaves von Willebrand factor. MPA a small-vessel vasculitis typically affects small blood vessels of lung kidney [1]. We present case concurrent which we believe could highlight pathogenetic correlation trea...