Preparation of chitosan (CS) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low CS molecular weight (MW) was investigated in this study. Diphtheria toxoid (DT) was used as a model antigen. The emulsion-solidification method was adopted for microencapsulation of DT.  In the first step, following the purification of semi-crude DT by the ion-exchan...

Microspheres were generated after subjecting corn stem rind to highpressure water pretreatment. These microspheres can be divided into two categories according to their location: free microspheres and adsorbed microspheres. The formation and characterization of both microsphere types were studied. For the free microspheres, the maximum formation was reached at 180 °C; when the temperature was t...

In the study we formulated the serratiopeptidase loaded cholic acid conjugated and unconjugated chitosan mucoadhesive microspheres. It was observed that the conjugated microspheres show better permeation rate than unconjugated microspheres. Moreover the permeation enhancer increased the % cumulative drug permeation through the mucosal membrane from 69.37 % to 74.39 % for unconjugated microspher...

Tungsten trioxide microspheres of 2–4 m diameter have been prepared by controlled oxidation of tungsten carbide microspheres. These microspheres are characterized by XRD, SEM, and HRTEM. The microspheres are made of WO3 nanoparticles with an average diameter of around 15 nm. Platinum supported on these WO3 microspheres exhibits higher and stable electrocatalytic activity for methanol oxidation ...

the cellular therapy and nerve tissue engineering will probably become a major therapeutic strategy for promoting axonal growth through injured area in central nervous system and peripheral nervous system in the coming years. the stem cell carrier scaffolds in nerve tissue engineering resulted in strong survival of cells and suitable differentiation into neural cells, so this pathway should be ...

A series of chitosan/attapulgite (CTS/APT) hybrid microspheres were prepared by a facile spray-drying technique. The developed hybrid microspheres were characterized by Fourier transform infrared spectra (FTIR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and the zeta potential. The encapsulation efficiency and in vitro controlled release properties of the microspheres fo...

One of the key advantages to a lab-on-a-chip system based on digital microfluidics is the reconfigurability and reusability of the same chip for different tasks. The ability to manipulate magnetic microspheres in solution on a lab-on-a-chip will expand the variety of tasks that can be performed if the microspheres are used as reagent immobilization surfaces. Because the microspheres can be tran...

An investigation into the suitability of mucuna gum microspheres for oral delivery of glibenclamide is presented. Mucuna gum microspheres were formulated under different conditions of polymer concentration and crosslinking time at constant speed. The formulated microspheres were thereafter loaded with glibenclamide by the remote loading process. The microspheres were evaluated according to part...

Microcapsules offer a wide variety of convenience in drug delivery when compared with conventional dosage forms. It is unique carrier system for many pharmaceuticals. Microencapsulation potential process which prolongs the efficacy significantly and improves patient compliance. This approach can alleviate limitations dose dumping, multiple inconvenience, kidney disease. form has advantages elde...

Phagocytosis of microspheres in V79 Chinese hamster lung cells was investigated by flow cytometry. Fluorescent microspheres (1.8 micron diameter) were used as the ingesta. Change in the number of V79 cells containing fluorescent microspheres was measured as an index of phagocytic activity. With time there was a sigmoidal increase in cells containing microspheres. The phagocytosis of microsphere...