نتایج جستجو برای: microtubuleassociated protein2
تعداد نتایج: 192 فیلتر نتایج به سال:
The self-assembly of tubulin devoid of microtubuleassociated proteins (MAPs) has been studied using a MES buffer containing dimethyl sulfoxide (MezSO). Between 6% and 12% v/v MeZSO, the tubulin forms polymers which resemble microtubules in their morphology and chemical properties. These MezSO microtubules, like normal microtubules, require GTP for assembly and are sensitive to cold, calcium ion...
In recent years, diagnosis and treatment of patients with advanced lung cancer have undergone transformational changes. The current paradigm for prescribing novel targeted therapies is based on selecting patients according to the presence of specific oncogenic abnormalities in the tumor. The efficacy of therapy targeted at a specific oncogene is convincing evidence of “oncogene addiction”, or t...
The control of organ growth by coordinating cell proliferation and differentiation is a fundamental developmental process. In plants, postembryonic root growth is sustained by the root meristem. For maintenance of root meristem size, the rate of cell differentiation must equal the rate of cell division. Cytokinin and auxin interact to affect the cell proliferation and differentiation balance an...
The ability of sterol carrier protein2 (SCP2) to mediate transfer of unesterified cholesterol from adrenal lipid inclusion droplets to mitochondria has been tested in an in vitro model system. Unlike mitochondrial utilization of cholesterol added in acetone or dimethyl sulfoxide, the unesterified cholesterol of lipid droplets did not provide a readily available source of substrate for mitochond...
BACKGROUND Recently, we reported cytoskeleton-associated protein2 (CKAP2) as a possible new prognostic breast cancer marker. However, it has not yet been applied in clinic. Therefore, clinical significance of CKAP2 was evaluated in comparison with that of Ki-67 in a cohort of breast cancer patients, and the expression difference was analyzed in cell cycle-arrested cancer and fibroblast cells. ...
In estrogen receptor–positive (ERþ) breast cancer cells, BCL2 overexpression contributes to antiestrogen resistance. Direct targeting of the antiapoptotic BCL2 members with GX15-070 (obatoclax), a BH3-mimetic currently in clinical development, is an attractive strategy to overcome antiestrogen resistance in some breast cancers. Recently, GX15-070 has been shown to induce both apoptosis and auto...
Many different proteins associate with microtubules, influencing their spatial organization and function. These include proteins of a structural nature, which link microtubules to one another or to other cellular organelles and which may stimulate tubulin assembly. The second group, the so-called dynamic microtubuleassociated proteins, move subcellular components along microtubules through nucl...
Alzheimer's disease is a fatal neurodegenerative disease whose principal clinical symptoms are cognitive ability and memory loss. The main pathological features of Alzheimer's disease are the formation of senile plaques in the brain, loss of neurons and synapses, tangles of neurofibrillary abnormal accumulation and reduction of cholinergic neurotransmitter. Aβ is used to be neurotoxin in AD mod...
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