This discussion will highlight the following 9 specific points that related to metabolic acidosis caused by various toxins. The current recommendation suggests that alcohol dehydrogenase inhibitor fomepizole is preferred to ethanol in treatment of methanol and ethylene glycol poisoning, but analysis of the enzyme kinetics indicates that ethanol is a better alternative. In the presence of a mode...

This research was carried out to assess the dechlorination and decomposition of Polychlorinated biphenyls (PCBs) in the real waste transformer oil using polyethylene glycol 1000/NaOH through a modified household microwave oven. To do so, the influence of polyethylene glycol (PEG) (1.5-7.5 g) and NaOH (0.3-1.5 g) under microwave (MW) power of 500 W on the dechlorination efficiency of PCBs, exist...

INTRODUCTION Every year about 2.4 million people in USA are exposed to toxic substances. Many of them are children below 6 years of age. Majority of poisonings in children are incidental and related to household products including for example drugs, cleaning products or antifreeze products. Antifreeze solutions contain ethylene glycol and methanol. Treatment of these toxic substances involves e...

BACKGROUND Increasing cell membrane permeability to water and cryoprotectants is critical for the successful cryopreservation of cells with large volumes. Artificial expression of water-selective aquaporins or aquaglyceroporins (GLPs), such as mammalian aquaporin-3 (AQP3), enhances cell permeability to water and cryoprotectants, but it is known that AQP3-mediated water and solute permeation is ...

BACKGROUND: Some herbal plants can prevent kidney stones formation in a dose dependent manner. In present study, we aimed to investigate the protective role of Cannabis sativa aqueous extraction on calcium oxalate formation in ethylene glycol-induced rats. MATERIALS AND METHODS: To evaluate anti-urolithiasis, variations of the main risk factors (citrate, phosphorous, calcium and PH) have been ...

To the Editor: We wish to substantiate the important observations of LeGatt and Tisdell (1) cautioning against the use of propylene glycol as an internal standard for quantifying ethylene glycol. A 32-yearold woman presented to our emergency department in an agitated state after the ingestion of multiple drugs in an attempted suicide. Gastric lavage and charcoal were administered as well as int...

OBJECTIVE To systematically review English-language articles on fomepizole administration in patients with ethylene glycol poisoning. DATA SOURCES MEDLINE, EMBASE, Current Contents, and PubMed. Search terms were fomepizole, 4-methylpyrazole, and ethylene glycol. The search was supplemented with a bibliographic review of all relevant articles. STUDY SELECTION All published reports of fomepiz...

The present investigation is an attempt to evaluate the effect of Bergenia ciliata extract on kidney of ethylene glycol induced urolithiasis in adult female Wistar rats. The hydro-alcoholic extract of Bergenia ciliata/standard drug cystone were administrated simultaneously at a dose of 150 and 300 mg/kg body weight/day, p.o. along with ethylene glycol (0.75% v/v) for 28 days. Significant change...

BACKGROUND Intoxication with ethylene glycol happen all around the world and without rapid recognition and early treatment, mortality from this is high. METHODS In our study, we retrospectively analysed six cases of ethylene glycol intoxication in our department. We measured ethylene glycol or glycolate levels, lactate levels and calculated the osmolal and anion gap. RESULTS Data from six p...

An ethynylhelicene oligomer [(M)-D-4]-C12-TEG with six tri(ethylene glycol) (TEG) groups at the termini was synthesized, and double-helix formation was studied using CD, UV-Vis, vapor pressure osmometry, dynamic light scattering, and H NMR. [(M)-D-4]-C12-TEG reversibly changed its structure between a double helix and a random coil in response to heating and cooling in aromatic solvents, non-aro...