it has been estimated that more than 1.7 million individuals suffer a traumatic brain injury (tbi) each year. tbi causes secondary biochemical and metabolic changes which contribute to subsequent tissue damage and associated neuronal cell death. two early and delayed events occur after tbi, which results in neurological deficits. primary injury events include the mechanical damage that occur at...

objective(s):melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.secondary injury following the primary traumatic brain injury (tbi) results in glial cells activation, especially astrocytes. in fact, astrocyte activation causes the production of pro-inflammatory cytokines...

traumatic brain injury (tbi) is defined as an external mechanical injury to the brain. neuroinflammation plays a vital role in the pathophysiology of tbi. microglia and astrocytes play a central role in the initiation and regulation of inflammation. numerous pro-inflammatory mediators including cytokines, chemokines, reactive oxygen species (ros) and nitric oxide (no) released by microglia. in ...

Traumatic brain injury (TBI) is a silent epidemic. Mild traumatic brain injury (mTBI) causes brain injury that results in electrophysiologic abnormalities visible on electroencephalography (EEG) recordings. The purpose of this brief review was to discuss the importance of EEG findings in traumatic brain injury. Relevant articles published during the 1996-2016 period were retrieved from Medline ...

The WHO Collaborating Centre for Neurotrauma Task Force on Mild Traumatic Brain Injury performed a comprehensive search and critical review of the literature published between 1980 and 2002 to assemble the best evidence on the epidemiology, diagnosis, prognosis and treatment of mild traumatic brain injury. Our primary sources of literature were Medline, Cinahl, PsycINFO and Embase. Citations we...

there are only a few, non-evidence based, neuroprotective strategies for treatment and prevention of brain injuries after closed head trauma. to establish new therapy strategies, a novel animal model is needed. the aim of our investigation was to link standardized small animal models and actual patient medical care. data of experimental small animal studies often cannot be transferred to cns in...

over half of all reported traumatic brain injuries are the result of a motor vehicle accident. other then the direct head impact itself, the sheer forces of the accident can cause the brain also to collide against the internal bone of the skull. in fact, when a moving head comes to a quick stop, the brain continues in its movement, striking the interior of the skull. this can cause bruising of ...

in recent years, the usefulness of intracranial pressure (icp) monitoring has been questioned in several reports for traumatic brain injury (tbi) management. therefore the needs of multidisciplinary groups of discussion of neurosurgeons and neurointensivists to update practical applications of icp in severe adult tbi has been advocated in many parts of the world. a consensus conference was held...

emotion regulation difficulties are from the factors that caused the incidents and automobile accidents and work related. this study aimed to comparing emotion regulation difficulties in mild traumatic brain injury (tbi) patients and normal people in kashan.the study was performed on 30 tbi patients referred to shahid beheshti hospital in kashan city and 30 normal people in kashan. tbi patients...

head trauma associated with multiple destructive cognitive symptoms. cognitive destruction leads to impairment in cognitive tasks and cognitive failure. cognitive failures include problems with memory, attention, and operation. this study aimed to comparing cognitive failures in mild traumatic brain injury (tbi) patients and normal people in kashan. the study was performed on 40 tbi patients re...