Milk thistle (Silybum marianum) is a popular herbal product used for hepatoprotection and chemoprevention. Two commercially available formulations are the crude extract, silymarin, and the semipurified product, silibinin. Silymarin consists of at least seven flavonolignans, of which the most prevalent are the diastereoisomers silybin A and silybin B; silibinin consists only of silybin A and sil...

BACKGROUND Extracts of milk thistle (MT), Silybum marianum, have been used as medical remedies since the time of ancient Greece. Methotrexate is a potentially hepatotxic drug. OBJECTIVES To clarify the hepatoprotective effects of MT on methotrexate. MATERIALS AND METHODS From January 2010 to April 2010, 30 male rats were recruited into three 10-rat subgroups in Tabriz University of Medical ...

Poor production of breast milk is the most frequent cause of breast lactation failure. Often, physician prescribe medications or other substances to solve this problem. The use of galactogogues should be limited to those situations in which reduced milk production from treatable causes has been excluded. One of the most frequent indication for the use of galactogogues is the diminution of milk ...

The outbreak of coronavirus disease-2019 (COVID-19) had a striking impact on the worldwide healthcare system within very short period. availability large number clinical data SARS-CoV-2, conventional precautionary majors, and treatment strategies with existing therapeutic antiviral drug molecules also fails to control progression disease transmission among population. Hence, we implemented phar...

Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla SER. var. thunbergii MAKINO, suppressed D-galactosamine-induced liver injury by 85.2% when added to the diet at 1% and fed to rats for fifteen days. The hepatoprotective effect is more potent than that of a milk thistle extract and turmeric powder. Some fractionated extracts showed hepatoprotective activity in the...