The etiology of cancer includes aberrant cellular homeostasis where a compromised RNA regulatory network is a prominent contributing factor. In particular, noncoding RNAs including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) were recently shown to play important roles in the initiation, progression, and metastasis of human cancers. Nonetheless, a mechanistic understanding of noncoding ...

MAGIA (miRNA and genes integrated analysis) is a novel web tool for the integrative analysis of target predictions, miRNA and gene expression data. MAGIA is divided into two parts: the query section allows the user to retrieve and browse updated miRNA target predictions computed with a number of different algorithms (PITA, miRanda and Target Scan) and Boolean combinations thereof. The analysis ...

The majority of plants are able to form the arbuscular mycorrhizal (AM) symbiosis in association with AM fungi. During symbiosis development, plant cells undergo a complex reprogramming resulting in profound morphological and physiological changes. MicroRNAs (miRNAs) are important components of the regulatory network of plant cells. To unravel the impact of miRNAs and miRNA-mediated mRNA cleava...

Pelteobagrus vachelli is a well-known commercial species in Asia. However, a sudden lack of oxygen will result in mortality and eventually to pond turnover. Studying the molecular mechanisms of hypoxia adaptation in fishes will not only help us to understand fish speciation and the evolution of the hypoxia-signaling pathway, but will also guide us in the breeding of hypoxia-tolerant fish strain...

Expression levels of mRNA molecules are regulated by different processes, comprising inhibition or activation by transcription factors (TF) and post-transcriptional degradation by microRNAs (miRNA). birta (Bayesian Inference of Regulation of Transcriptional Activity) uses the regulatory networks of TFs and miRNAs together with mRNA and miRNA expression data to infer switches of regulatory activ...

Estrous cycle is one of the placental mammal characteristics after sexual maturity, including estrus stage (ES) and diestrus (DS). important in female physiology its disorder may lead to diseases, such as polycystic ovary syndrome, ovarian carcinoma, anxiety, epilepsy. In latest years, effects non-coding RNAs messenger RNA (mRNA) on estrous have started arouse much concern, however, a whole tra...

The present study was performed to identify the dysregulated microRNAs (miRNAs/miRs) and mRNAs, and enriched pathways involved in nasopharyngeal carcinoma (NPC) through the establishment of an miRNA‑mRNA‑pathways network. mRNA and miRNA expression profiles were collected from the European Molecular Biology Laboratory‑European Bioinformatics Institute. Differentially expressed genes and differen...

Abstract Objectives Hepatocellular carcinoma (HCC) is one of the most common causes cancer-related deaths, due to high morbidity, a low early diagnosis rate, and poor prognosis. It essential explore competitive endogenous RNA (ceRNA) arrays for prognosis HCC. Methods The original gene expression profiles differentially expressed lncRNA, miRNA mRNA in HCC were downloaded from TCGA database. Diff...

While a growing body of evidence implicates regulatory miRNA modules in various aspects of human disease and development, insights into specific miRNA function remain limited. Here, we present an innovative approach to elucidate tissue-specific miRNA functions that goes beyond miRNA target prediction and expression correlation. This approach is based on a multi-level integration of correspondin...

Tapping panel dryness (TPD), a complex physiological syndrome associated with the rubber tree (Hevea brasiliensis Muell. Arg.), causes cessation of latex drainage upon tapping and thus threatens production. Rubber virus 1 (RTV1) is novel positive-sense single-stranded RNA from Betaflexiviridae (genus Capillovirus), which has been established to cause TPD. MicroRNAs (miRNAs) play an important ro...