it was known that il-1β-induced rapid expression of mir-146a, which regulated the secretion of inflammatory chemokines in human a549 alveolar epithelial cells. however, little is known about the level of primary mir-146a and the downstream biogenesis of mir-146a in a549 cells. we examined the levels of primary mir-146a and mature mir-146a in a549 cells following treatment with pharmacological i...

objective: the current methods for bladder cancer diagnosis suffer from low sensitivity and specificity. therefore, finding a novel tumor markers with high specificity and sensitivity is of great interest. micrornas (mirna, mir) are small endogenously-produced, non-coding rnas with an important role in regulating gene expression. recent studies show that mirnas expression profiles represent sig...

objective: prostate cancer is the fifth most common cancer. in 2012, it was the second leading cause of cancer death for men worldwide. the pi3k/akt pathway plays an essential role in pathogenesis of prostate cancer; the key role of this pathway in cancer progression makes it an attractive target for prostate cancer therapy. micrornas (mirnas) that regulate gene expression have a special abilit...

Brain arteriovenous malformations (AVMs) are abnormal vessels that prone to rupture, causing life-threatening intracerebral hemorrhage (ICH). Understanding the molecular basis of pathogenesis, timely diagnosis, and treatment brain AVMs some urgent problems in neurosurgery. MicroRNAs (miRNAs) small endogenous RNAs regulate gene-expression posttranscriptionally. MiRNAs involved almost all biologi...

Cardiovascular diseases are the most common causes of human morbidity and mortality despite significant therapeutic improvements by surgical or pharmacological approaches in the last decade. MicroRNAs (miRNAs) have a significant role in diseases development or response to treatment. In this review, we summarized the role of miRNAs in the pathogenesis or the treatment of coronary artery disease ...

The current outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)in China threatened humankind worldwide. The coronaviruses contains the largest RNA genome among all other known RNA viruses, therefore the disease etiology can be understood by analyzing the genome sequence of SARS-CoV-2. In this study, we used an ab-intio based computational tool VMir to scan the complete geno...

MicroRNAs (miRNAs, miRs) are small endogenous non-coding RNAs that regulate the expression of protein-encoding genes at the post-transcriptional level. Several studies have described the role of miRNAs in T-cell acute lymphoblastic leukemia (T-ALL), including tumor suppressor and oncogenic miRNAs. Down-regulation of miRNA expression is a prominent feature of human malignancy. This down-regulati...

Mango is a major tropical fruit in the world and known as king of fruits because its flavor, aroma, taste, nutritional values. Although various regulatory roles microRNAs (miRNAs) long non-coding RNAs (lncRNAs) have been investigated many plants, there yet an absence such study mango. This first to provide information on (ncRNAs) mango with aims identifying miRNAs lncRNAs discovering their pote...