Treatments for gastroparesis have been unsatisfactory. We describe a patient with gastroparesis who did not respond to a series of conventional prokinetic treatments. Finally, an antidepressant, mirtazapine, was administered, and the patient's symptoms and gastric emptying showed surprisingly rapid improvement. Therefore, we recommend mirtazapine as a treatment for gastroparesis refractory to c...

Mirtazapine {1,2,3,4,10,14b-hexa-hydro-2-meth-ylpyrazino [2,1a] pyrido [2,3-c]benzazepin} is a tetracyclic compound with antidepressant activity in human [1]. Mirtazapine has a unique mechanism of action, different from that of the classical tricyclic antidepressants, the serotonin selective reuptake inhibitors and monoamine oxidase inhibitors, and could be described as a noradrenergic and spec...

BACKGROUND Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve treatment of the negative and certain cognitive symptoms of schizophrenia. METHODS The aim of the present study was to evaluate the effect of mirtazapine and risperidone, given separately or jointly, on the impact of MK-801(an NMDA receptor antagonist), ...

Introduction: Cancer patients often have concurrent physical and psychological symptoms. These problems may become barriers towards the healing process. Antidepressants seem to be beneficial for the purpose of palliative care in this type of patients. One of the useful medications is mirtazapine, which is known as noradrenergic and specific serotonergic antidepressant (NaSSA). This paper examin...

Background: Mirtazapine, a clinically effective antidepressant, acts by antagonizing central a2-adrenergic and 5-HT2/5-HT3 receptors. No data are available regarding mirtazapine’s effects on sleep architecture in patients with major depressive disorder. Methods: Six patients meeting criteria for major depressive disorder and scoring $4 on the three Hamilton Depression Rating Scale sleep items w...

Our previous studies showed that some of the tested antidepressants (tricyclics, SSRIs, mirtazapine, nefazodone) directly inhibited the metabolism of caffeine when added in vitro to liver microsomes. The aim of the present study was to investigate a possible indirect effect of prolonged in vivo administration of these antidepressants on the rate of caffeine oxidative metabolism: 1-N-, 3-N- and ...

OBJECTIVE Studies indicate that serotoninergic and noradrenergic pathophysiological mechanisms may underlie both alcohol abuse/dependence and depressive disorder. The purpose of this study was to evaluate and compare the effectiveness and tolerability of two serotonergic and noradrenergic antidepressant drugs-mirtazapine and amitriptyline, for the treatment of patients with alcohol dependence c...

OBJECTIVE To review the literature examining the use of mirtazapine with an emphasis on its therapeutic benefits for psychiatric patients with comorbid medical conditions. DATA SOURCES MEDLINE, PsycINFO, Global Health, and AGRICOLA were searched using the terms mirtazapine OR Remeron. Limits were English language, human, year 1980-2012, treatment and prevention, and therapy. STUDY SELECTION...