نتایج جستجو برای: mitochondrial permeability transitional pores
تعداد نتایج: 208838 فیلتر نتایج به سال:
We investigated whether genetic radiosensitivity-related changes in mtDNA/nDNA ratios are significant to mitochondrial function and if a material effect on mtDNA content and function exists. BALB/c (radiosensitive), C57BL/6 (radioresistant), and F1 hybrid mouse strains were exposed to total body irradiation. Hepatic genomic DNA was extracted, and mitochondria were isolated. Mitochondrial oxygen...
Introduction Mitochondrial Ca 2+ homeostasis is crucial for balancing cell survival and death (Giacomello et al., 2007; Duchen et al., 2008). Mitochondrial Ca 2+ uptake mechanisms across the inner mitochondrial membrane (IMM) are especially important for the regulation of ATP synthesis , the amplitude and spatiotemporal patterns of intra-cellular Ca 2+ transients, the mitochondrial fission–fusi...
AbstractInhibition of sperm motility has recently become a promising target for male contraceptive development. AF-2364, an analogue of Lonidamine (LND), had a contraceptive effect when orally administered to adult Sprague-Dawley rats. LND can also target mitochondria to inhibit oxygen consumption and block energy metabolism in tumour cells. However, there are no reports of the effects of AF-23...
Molecular size is one of the key determinants of transvascular transport of therapeutic agents in tumors. However, there are no data in the literature on the molecular size dependence of microvascular permeability in tumors. Therefore, we measured microvascular permeability to various macromolecules in the human colon adenocarcinoma LS174T transplanted in dorsal skin chambers in severe combined...
Recently, a mathematical model of the mitochondrial apoptotic pathway was proposed. In that study, the robustness of different simplified signaling models with respect to parameter changes was also investigated. It was found that bistability achieved via cooperative ultrasensitivity is ‘‘much more robust’’ than other mechanisms such as inhibitor ultrasensitivity. We reinvestigate this interesti...
We propose a mathematical model for mitochondria-dependent apoptosis, in which kinetic cooperativity in formation of the apoptosome is a key element ensuring bistability. We examine the role of Bax and Bcl-2 synthesis and degradation rates, as well as the number of mitochondrial permeability transition pores (MPTPs), on the cell response to apoptotic stimuli. Our analysis suggests that cooperat...
Abstract Hydrogen sulfide (H 2 S) can alleviate Cd-induced cell death, but the molecular mechanisms are not clear. To shed light on these mechanisms, death induced by 200 μM cadmium chloride in cucumber seedlings root tips was used as a model system. Here, we report that negative effect of Cd stress mitochondrial physiological functions include changes cytochrome c/a, membrane permeability tran...
Acetaminophen hepatotoxicity is the leading cause of druginduced liver failure. Despite substantial efforts in the past, the mechanisms of acetaminophen-induced liver cell injury are still incompletely understood. Recent advances suggest that reactive metabolite formation, glutathione depletion, and alkylation of proteins, especially mitochondrial proteins, are critical initiating events for th...
Acetaminophen hepatotoxicity is the leading cause of drug-induced liver failure. Despite substantial efforts in the past, the mechanisms of acetaminophen-induced liver cell injury are still incompletely understood. Recent advances suggest that reactive metabolite formation, glutathione depletion, and alkylation of proteins, especially mitochondrial proteins, are critical initiating events for t...
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