نتایج جستجو برای: mitogens
تعداد نتایج: 18446 فیلتر نتایج به سال:
Severe asthma is characterized by increased airway smooth muscle (ASM) mass due, in part, to ASM cell growth and contractile protein expression associated with increased protein synthesis. Little is known regarding the combined effects of mitogens and interferons on ASM cytosolic protein synthesis. We demonstrate that human ASM mitogens including PDGF, EGF, and thrombin stimulate protein synthe...
B lymphocytes can be induced to divide and form Ig-secreting clones either by Tcell help or by mitogens (1, 2). About one in three splenic lymphocytes respond to Bcell mitogens, and such activation is polyclonal: 1 clone in 1,000 produces antibodies against sheep erythrocytes (SRC), 1 1 in 500 against horse erythrocytes (HRC), and 1 in 50 against trinitrophenyl (TNP) (3-5). The presence of mito...
BACKGROUND The ability of cyclin-dependent kinases (CDKs) to promote cell proliferation is opposed by cyclin-dependent kinase inhibitors (CKIs), proteins that bind tightly to cyclin-CDK complexes and block the phosphorylation of exogenous substrates. Mice with targeted CKI gene deletions have only subtle proliferative abnormalities, however, and cells prepared from these mice seem remarkably no...
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