Introduction: There have been no randomized controlled trials (RCTs) evaluating the clinical or economic benefit of mitomycin C intravesical therapy vs. radical cystectomy in patients with high-risk non-muscle invasive bladder cancer (NMIBC). We used the Archimedes computational model to simulate RCT comparing radical cystectomy versus intravesical mitomycin C (MMC) therapy to evaluate the clin...

As the markets of mobile devices are expanding, needs for developing reliable memory cards are increasing, too. Samsung, one of the major players in memory card business, is also trying to improve the validation process for their memory card products. To this aim, we conducted a pilot project where a formal method and a specification-based testing technique are adopted to validate our MMC (Mult...

PURPOSE To determine the effect of a sustained-release dexamethasone implant (Ozurdex(®)) on wound healing after glaucoma filtration surgery in a rabbit model. METHODS Twelve new zealand white rabbits were divided into three groups: filtration surgery with intraoperative subconjunctival implantation of Ozurdex(®) (n=6), filtration surgery with intraoperative topical application of mitomycin-C...

The interaction of hyperthermia and mitomycin C (MMC) was studied in wild-type Chinese hamster ovary cells and in Chinese hamster ovary cells selected for resistance to MMC. Hyperthermic potentiation of MMC activity was maximal if heating was done simultaneously, or up to 3 h following MMC exposure. Heat enhanced the effect of MMC in both drug-sensitive and -resistant cells. Dose enhancement ra...

Conjugates of mitomycin C (MMC) with estradiol bezoate and estradiol via glutaric acid (EB-glu-MMC and E-glu-MMC, respectively) were examined for their antitumor activities against P388 leukemia and sarcoma 180. EB-glu-MMC and E-glu-MMC were suspended in 10% (v/v) propylene glycol in saline and administered intraperitoneally to mice bearing P388 leukemia intraperitoneally or to mice bearing sar...

T main goal of this paper is to describe a new multistage Monte Carlo (MMC) simulation method for solving influence diagrams using local computation. Global methods have been proposed by others that sample from the joint probability distribution of all the variables in the influence diagram. However, for influence diagrams having many variables, the state space of all variables grows exponentia...

The ac/ac modular multilevel converter (MMC) application in the electric railway poses new challenges to stability of system. impedance analysis method is an effective way assess MMC-based systems. Due internal dynamics MMC, there are steady-state harmonic components arm currents and capacitor voltages, these have a significant impact on dynamic characteristics MMCs. To accurately predict syste...

This paper shows that a strategic but purely competitive e ect of multi-market contact (MMC) can change the quantity provided by a multimarket rm by as much as 50%. Multi-market rms serve some but not all of their rivals' markets. As a result, a rm's reaction to rivals' actions in one market depends on the conditions in other markets served by the rm. Moreover, a rm's move in one market may a e...

The effect of molybdenum (Mo) on the microstructure and creep behavior of nominally Ti–24Al– 17Nb (at.%) alloys and their continuously reinforced SiCfiber composites (fiber volume fraction = 0.35) was investigated. Constant-load, tensile-creep experiments were performed in the stress range of 10–275 MPa at 650 C in air. A Ti–24Al–17Nb–2.3Mo (at.%) alloy exhibited significantly greater creep res...

Cellular interaction and in vitro antitumor activity of a polymeric prodrug of mitomycin C (MMC), mitomycin C-dextran conjugate (MMC-D), were studied in relation to its physicochemical characteristics. MMC-D with cationic and anionic charges were examined. The cationic MMC-D was synthesized using a spacer, epsilon-aminocaproic acid and dextrans with molecular weights of 10,000, 70,000, or 500,0...